Rochette Amber D, Spitznagel Mary Beth, Strain Gladys, Devlin Michael, Crosby Ross D, Mitchell James E, Courcoulas Anita, Gunstad John
Department of Psychological Sciences, Kent State University, Kent, Ohio, USA.
Department of Surgery, Weill Cornell Medical College, New York, New York, USA.
Obesity (Silver Spring). 2016 Jul;24(7):1427-9. doi: 10.1002/oby.21514. Epub 2016 May 26.
This study examines the prevalence of mild cognitive impairment (MCI) in a sample of adults with severe obesity and whether undergoing bariatric surgery reduces the frequency of MCI.
A total of 171 participants with severe obesity (mean age = 43.07 ± 11.21) completed computerized cognitive testing. A subset of participants underwent bariatric surgery as part of the Longitudinal Assessment of Bariatric Surgery project. MCI was operationalized using commonly used criteria to establish prevalence in the overall sample and to examine possible changes after bariatric surgery.
More than half of the overall sample met criteria for MCI at baseline (53.8%), and MCI was prevalent even in young and middle-aged adults with severe obesity. Within the subset of participants who underwent bariatric surgery, the prevalence of MCI was reduced by 48.9% at 12-month follow-up (from 53.4% to 27.3%).
Findings suggest that many individuals with severe obesity meet criteria for MCI and that prevalence rates decline after bariatric surgery. A better understanding of the mechanisms linking severe obesity to adverse neurological outcomes is much needed.
本研究调查重度肥胖成年人样本中轻度认知障碍（MCI）的患病率，以及接受减肥手术是否会降低MCI的发生率。
共有171名重度肥胖参与者（平均年龄=43.07±11.21）完成了计算机化认知测试。作为减肥手术纵向评估项目的一部分，一部分参与者接受了减肥手术。使用常用标准对MCI进行操作化定义，以确定总体样本中的患病率，并检查减肥手术后可能发生的变化。
超过一半的总体样本在基线时符合MCI标准（53.8%），即使在重度肥胖的中青年成年人中，MCI也很普遍。在接受减肥手术的参与者子集中，12个月随访时MCI的患病率降低了48.9%（从53.4%降至27.3%）。
研究结果表明，许多重度肥胖个体符合MCI标准，减肥手术后患病率下降。非常需要更好地了解将重度肥胖与不良神经学结果联系起来的机制。
