Zhao Hua, Wilkinson Anna, Shen Jie, Wu Xifeng, Chow Wong-Ho
Departments of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael and Susan Dell Center for Healthy Living, University of Texas School of Public Health, Austin Regional Campus, Austin, TX, USA.
Pediatr Obes. 2017 Oct;12(5):356-362. doi: 10.1111/ijpo.12151. Epub 2016 May 27.
Obesity is associated with multiple health problems and often originates in childhood. The purpose is to investigate the associations of genetic polymorphisms in genes related to risk-taking behaviours with body mass index (BMI) trajectory over adolescence among Mexican Americans.
This study included 1229 Mexican American adolescents who participated in a large population-based cohort study in Houston, Texas. BMI data were obtained at baseline and two follow-ups. The median follow-up time was 59 months. Participants were genotyped for 672 functional and tagging variants in genes involved in the dopamine, serotonin and cannabinoid pathways.
After adjusting for multiple comparisons, three genetic variants, namely, rs933271 and rs4646310 in COMT gene, and rs9567733 in HTR2A gene were significantly associated with BMI growth over adolescence. Using those three variants, we created an allelic score, and the allelic score was associated with BMI growth over adolescence (P < 0.001). With the increase number of variant allele, the rate of BMI growth over adolescence was slower. Finally, we identified another two genetic variants, namely, rs17069005 in HTR2A gene and rs3776511 in SLC6A3A gene were associated with obesity at last follow-up.
The results suggest that genetic variants in selected genes involved in dopamine and serotonin pathways have noticeable effects on BMI over adolescence.
肥胖与多种健康问题相关，且往往始于儿童期。本研究旨在探讨与冒险行为相关基因的遗传多态性与墨西哥裔美国人青少年时期体重指数（BMI）轨迹之间的关联。
本研究纳入了1229名墨西哥裔美国青少年，他们参与了德克萨斯州休斯顿一项基于大规模人群的队列研究。在基线和两次随访时获取BMI数据。中位随访时间为59个月。对参与多巴胺、血清素和大麻素途径的基因中的672个功能性和标签变体进行基因分型。
在调整多重比较后，三个基因变体，即COMT基因中的rs933271和rs4646310，以及HTR2A基因中的rs9567733与青少年时期的BMI增长显著相关。利用这三个变体，我们创建了一个等位基因评分，该评分与青少年时期的BMI增长相关（P < 0.001）。随着变体等位基因数量的增加，青少年时期BMI的增长速度较慢。最后，我们确定另外两个基因变体，即HTR2A基因中的rs17069005和SLC6A3A基因中的rs3776511与最后一次随访时的肥胖相关。
结果表明，参与多巴胺和血清素途径的特定基因中的遗传变体对青少年时期的BMI有显著影响。
