遗传、心理和人际网络因素与美国墨西哥裔青少年 2 年内 binge drinking 变化的相关性。
Genetic, Psychological, and Personal Network Factors Associated With Changes in Binge Drinking Over 2 Years Among Mexican Heritage Adolescents in the USA.
机构信息
Department of Healthy Living, Health Risk Prevention Team, Korea Health Promotion Institute, Jung-gu, Seoul, Republic of Korea.
Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Ann Behav Med. 2019 Feb 1;53(2):126-137. doi: 10.1093/abm/kay019.
BACKGROUND
Despite prevalent binge drinking and alcohol-dependent symptoms among Hispanics, few studies have examined how multidimensional factors influence Hispanic adolescents' binge drinking. Purpose This study examines the effects of genetic, psychological, and social network factors on binge drinking over time among Mexican heritage adolescents in the USA and whether there are correlations among genetic variants that are associated with binge drinking and psychological and network characteristics.
METHODS
Mexican heritage adolescents (n = 731) participated in a longitudinal study, which included genetic testing at baseline, alcohol use assessments at first and second follow-ups, and questionnaires on sensation seeking, impulsivity, and peer and family network characteristics at second follow-up. Logistic regression and Spearman correlation analyses were performed.
RESULTS
After adjusting for demographic characteristics, underlying genetic clustering, and binge drinking at first follow-up, two genetic variants on tryptophan hydroxylase 2 (TPH2; rs17110451, rs7963717), sensation seeking and impulsivity, and having a greater fraction of peers who drink or encourage drinking alcohol were associated with greater risk whereas another genetic variant on TPH2 (rs11178999) and having a greater fraction of close family relationships were associated with reduced risk for binge drinking at second follow-up. Genetic variants in TPH1 (rs591556) were associated with sensation seeking and impulsivity, while genetic variants in TPH2 (rs17110451) were associated with the fraction of drinkers in family.
CONCLUSIONS
Results reveal that genetic variants in the serotonin pathway, behavioral disinhibition traits, and social networks exert joint influences on binge drinking in Mexican heritage adolescents in the USA.
背景
尽管西班牙裔人群普遍存在狂饮和酒精依赖症状，但很少有研究探讨多维因素如何影响西班牙裔青少年的狂饮行为。目的：本研究考察了遗传、心理和社交网络因素对美国墨西哥裔青少年随时间推移 binge drinking 的影响，以及与 binge drinking 相关的遗传变异与心理和网络特征之间是否存在相关性。
方法
墨西哥裔青少年（n=731）参与了一项纵向研究，该研究包括基线时的基因检测、第一次和第二次随访时的饮酒评估，以及第二次随访时的感觉寻求、冲动性以及同伴和家庭网络特征的问卷。进行了逻辑回归和 Spearman 相关分析。
结果
在调整了人口统计学特征、潜在的遗传聚类和第一次随访时的 binge drinking 后，色氨酸羟化酶 2（TPH2；rs17110451，rs7963717）上的两个遗传变异、感觉寻求和冲动性、以及有更多的同伴饮酒或鼓励饮酒的比例与更高的风险相关，而 TPH2 上的另一个遗传变异（rs11178999）和有更多的亲密家庭关系与第二次随访时 binge drinking 的风险降低相关。TPH1（rs591556）上的遗传变异与感觉寻求和冲动性相关，而 TPH2（rs17110451）上的遗传变异与家庭中饮酒者的比例相关。
结论
结果表明，血清素途径中的遗传变异、行为抑制特质和社交网络对美国墨西哥裔青少年 binge drinking 有共同影响。
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