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两种磷酸钙/胶原蛋白复合材料力学性能及其对脂肪干细胞成骨作用的比较评价

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells.

作者信息

Li Qing, Wang Tong, Zhang Gui-Feng, Yu Xin, Zhang Jing, Zhou Gang, Tang Zhi-Hui

机构信息

National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China; Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China; 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.

2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.

出版信息

Stem Cells Int. 2016;2016:6409546. doi: 10.1155/2016/6409546. Epub 2016 Apr 28.

DOI:10.1155/2016/6409546
PMID:27239204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4864572/
Abstract

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.

摘要

脂肪来源干细胞（ADSCs）是用于骨组织工程的理想种子细胞，与其他干细胞相比具有许多优势。在本研究中，制备了两种磷酸钙/胶原蛋白复合支架，并研究了它们对ADSCs增殖和成骨分化的影响。具有额外β-磷酸三钙的羟基磷灰石/β-磷酸三钙（HA/β-TCP）复合支架（HTPSs）能使ADSCs更好地增殖，并显示出促进成骨的作用。因此，这种复合支架与ADSCs联合使用或单独使用，在骨再生及骨缺损的潜在临床治疗中具有应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/6f427112671f/SCI2016-6409546.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/d874ad12fcc2/SCI2016-6409546.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/f5ee11140ea9/SCI2016-6409546.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/5c99904de156/SCI2016-6409546.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/141c9cd99ee4/SCI2016-6409546.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/f8758033e20a/SCI2016-6409546.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/9c4dd9e5dc68/SCI2016-6409546.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/480faa57a33f/SCI2016-6409546.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/a78fb2b9e369/SCI2016-6409546.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/6f427112671f/SCI2016-6409546.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/d874ad12fcc2/SCI2016-6409546.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/f5ee11140ea9/SCI2016-6409546.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/5c99904de156/SCI2016-6409546.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/141c9cd99ee4/SCI2016-6409546.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/f8758033e20a/SCI2016-6409546.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/9c4dd9e5dc68/SCI2016-6409546.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/480faa57a33f/SCI2016-6409546.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/a78fb2b9e369/SCI2016-6409546.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6404/4864572/6f427112671f/SCI2016-6409546.009.jpg

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