Algahtani Hussein, Subahi Ahmad, Shirah Bader
King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia.
Case Rep Neurol Med. 2016;2016:3502683. doi: 10.1155/2016/3502683. Epub 2016 Apr 28.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.
中东呼吸综合征冠状病毒（MERS-CoV）于2012年9月在沙特阿拉伯首次被发现。自那时以来，它已导致1600多例实验室确诊病例，其中死亡人数超过580人。该疾病的临床病程范围从无症状感染到伴有多器官受累和死亡的严重下呼吸道疾病。该疾病可引起肺部、肾脏、血液学和胃肠道并发症。在本文中，我们报告了两名成年患者中MERS-CoV的神经并发症，并对其病理生理学进行了推测。首例患者因血小板减少、弥散性血管内凝血和血小板功能障碍而发生脑出血。第二例是长期入住重症监护病房（ICU）并发危重病性多神经病的病例。在这些病例中，神经并发症继发于全身并发症和长期入住ICU。需要进行尸检研究以进一步了解其病理机制。
