中东呼吸综合征：疫苗研发的现状与未来前景
Middle East respiratory syndrome: current status and future prospects for vaccine development.
作者信息
Du Lanying, Jiang Shibo
机构信息
a 1 Lindsley F. Kimball Research Institute, New York Blood Center , NY, USA +1 212 570 3459 ;
b 2 Fudan University, Shanghai Medical College and Institute of Medical Microbiology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health , Shanghai, China +1 212 570 3058 ;
出版信息
Expert Opin Biol Ther. 2015;15(11):1647-51. doi: 10.1517/14712598.2015.1092518. Epub 2015 Sep 28.
Abstract
The outbreaks of Middle East respiratory syndrome (MERS) previously in Middle East and recently in South Korea have raised serious concerns worldwide, reinforcing the importance of developing effective and safe vaccines against MERS-coronavirus (MERS-CoV). A number of vaccine candidates have been developed on the basis of viral vectors, recombinant proteins, DNAs, nanoparticles, and recombinant MERS-CoV, and some of them have shown efficacy in laboratory animals. However, the paucity of financial support has made it difficult to transfer effective candidates from the preclinical stage to clinical trials. Here, we summarize currently available MERS vaccine candidates and illustrate strategies for future development, with the aim of provoking government agencies and Big Pharma to invest more funds for developing efficacious and safe MERS vaccines.
摘要
先前在中东以及近期在韩国爆发的中东呼吸综合征（MERS）在全球范围内引起了严重关注，凸显了研发针对中东呼吸综合征冠状病毒（MERS-CoV）的有效且安全疫苗的重要性。基于病毒载体、重组蛋白、DNA、纳米颗粒以及重组MERS-CoV，已经研发出了多种候选疫苗，其中一些在实验动物身上显示出了疗效。然而，资金支持的匮乏使得将有效的候选疫苗从临床前阶段推进到临床试验变得困难。在此，我们总结了目前可用的MERS候选疫苗，并阐述了未来的发展策略，目的是促使政府机构和大型制药公司投入更多资金来研发有效且安全的MERS疫苗。
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