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补骨脂素和异补骨脂素改善雌性和雄性小鼠性激素缺乏诱导的骨质疏松症。

Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice.

作者信息

Yuan Xiaomei, Bi Yanan, Yan Zeman, Pu Weiling, Li Yuhong, Zhou Kun

机构信息

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China.

出版信息

Biomed Res Int. 2016;2016:6869452. doi: 10.1155/2016/6869452. Epub 2016 Apr 30.

DOI:10.1155/2016/6869452
PMID:27239473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4867056/
Abstract

Osteoporosis is a systemic skeletal disease, which is characterized by a systemic destruction of bone mass and microarchitecture. With life standard improved, the treatment of osteoporosis attracted more attention. The aim of this study is to verify the osteoprotective effect of psoralen and isopsoralen in females and males. Female and male mice were divided into 7 groups in this study: control group (sham-operation), model group (by ovariectomy or orchidectomy), positive control group (females given estradiol valerate; males given alendronate sodium), psoralen groups (10 mg/kg and 20 mg/kg), and isopsoralen groups (10 mg/kg and 20 mg/kg). After administration of psoralen and isopsoralen for 8 weeks, osteoporosis was ameliorated with increasing bone strength and improving trabecular bone microstructure as indicated by CT scan and pathology. Serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRACP), osteocalcin (OC), and C-terminal cross-linking telopeptides of type I collagen (CTX-1) were examined. Decreased TRACP and increased ALP/TRACP suggested restoring from bone destruction. These results suggest that psoralen and isopsoralen may be used as good natural compounds for the treatment of osteoporosis in males, as well as females.

摘要

骨质疏松症是一种全身性骨骼疾病，其特征是骨量和微结构的系统性破坏。随着生活水平的提高，骨质疏松症的治疗受到了更多关注。本研究的目的是验证补骨脂素和异补骨脂素对雌性和雄性动物的骨保护作用。在本研究中，将雌性和雄性小鼠分为7组：对照组（假手术）、模型组（卵巢切除或睾丸切除）、阳性对照组（雌性给予戊酸雌二醇；雄性给予阿仑膦酸钠）、补骨脂素组（10mg/kg和20mg/kg）和异补骨脂素组（10mg/kg和20mg/kg）。补骨脂素和异补骨脂素给药8周后，骨质疏松症得到改善，骨强度增加，小梁骨微结构改善，CT扫描和病理学结果表明了这一点。检测血清碱性磷酸酶（ALP）、抗酒石酸酸性磷酸酶（TRACP）、骨钙素（OC）和I型胶原C端交联端肽（CTX-1）。TRACP降低和ALP/TRACP升高表明骨破坏得到恢复。这些结果表明，补骨脂素和异补骨脂素可作为治疗男性和女性骨质疏松症的良好天然化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/67da51b9632d/BMRI2016-6869452.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/42161ed6c452/BMRI2016-6869452.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/352f58936186/BMRI2016-6869452.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/3a61bdbfa6f4/BMRI2016-6869452.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/3436e507857a/BMRI2016-6869452.004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/67da51b9632d/BMRI2016-6869452.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/42161ed6c452/BMRI2016-6869452.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/352f58936186/BMRI2016-6869452.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/3a61bdbfa6f4/BMRI2016-6869452.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/3436e507857a/BMRI2016-6869452.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/634c0a381d70/BMRI2016-6869452.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c89/4867056/67da51b9632d/BMRI2016-6869452.006.jpg

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