Department of Chemistry, Sahmyook University, Seoul, 01795, Korea.
Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea.
Nanoscale. 2016 Jun 9;8(23):11949-55. doi: 10.1039/c6nr00362a.
Versatile drug delivery devices using nanoporous membranes consisting of gold nanorods and dendrimers have been demonstrated to provide light-triggered on-demand pulsatile release from a reservoir containing highly enriched therapeutics for a real patient's needs. The drug release rate is directly correlated with the temperature increase and irradiated energy of a near-IR laser in both static and fluidic devices. This biocompatible platform for on-demand control was further confirmed by in vitro experiments. Interestingly, different responses to stimuli were obtained from each drug in the absence and presence of NIR light, indicating the versatile potential of our on-demand drug delivery system in less-invasive therapies requiring multi-drug delivery strategies. The enhanced delivery system will improve therapeutic efficacy and reduce side effects through regulation of plasma drug profiles.
采用金纳米棒和树枝状大分子组成的多孔膜的多功能药物输送装置已经被证明可以提供按需的光触发脉冲释放，从含有高度浓缩治疗剂的储液器中按需释放，以满足真实患者的需求。药物释放率与静态和流动装置中近红外激光的温度升高和辐照能量直接相关。这种用于按需控制的生物相容性平台通过体外实验得到了进一步证实。有趣的是，在没有和存在近红外光的情况下，每种药物对刺激的反应都不同，这表明我们的按需药物输送系统在需要多药物输送策略的微创治疗中具有多功能潜力。通过调节血浆药物谱，增强的输送系统将提高治疗效果并减少副作用。
