Faculty of Health and Life Sciences, Coventry University, Coventry, UK.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Korean J Intern Med. 2020 Nov;35(6):1385-1399. doi: 10.3904/kjim.2019.049. Epub 2020 Feb 19.
BACKGROUND/AIMS: Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials.
We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratified analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes.
An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, -2.04; 95% confidence interval, -2.82 to -1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure.
Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms.
背景/目的：全球高血压发病率估计超过 10 亿人，鉴于可溶性膳食纤维，特别是车前子，对高血压患者的血压有积极影响，因此，就其补充达成共识具有临床重要性。因此，本研究旨在系统地综述和荟萃分析车前子补充剂对高血压患者血压的影响的随机对照试验。
我们检索了六个通用数据库，包括 Pubmed/Medline、Ovid、Cochrane Library、Google Scholar、Embase 和 Scopus，直到 2018 年 11 月。同时进行了联合和分层分析。使用固定效应或随机效应模型评估平均效应大小。
最终有 11 项试验，592 名参与者被认为符合纳入本荟萃分析的标准。荟萃分析显示，收缩压显著降低 2.04mmHg（加权均数差，-2.04；95%置信区间，-2.82 至-1.63；p<0.001）。而荟萃回归强调，车前子的降压作用在基线血压较高的受试者中更强。
鉴于车前子具有广泛的益处，且无报道的副作用，特别是对高血压患者，医疗保健提供者和临床医生应考虑使用车前子补充剂来治疗或减轻高血压或高血压症状。
