Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi M-R, Hekmatdoost A
Students' Research Office, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Andrology and Embryology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Andrologia. 2017 Apr;49(3). doi: 10.1111/and.12624. Epub 2016 Jun 1.
The association of dietary nutrient patterns and sperm motility is not yet well elucidated, and previous studies have just focused on the isolated nutrients. This case-control study examined the association of nutrient patterns with asthenozoospermia among Iranian men. In total, 107 incident asthenozoospermic men and 235 age-matched controls were interviewed through the infertility clinics in Tehran, Iran, from January 2012 to November 2013. Semen quality data were analysed according to the fifth edition of WHO guideline. Nutrient patterns were identified using principal component analysis based on semiquantitative 168-item food frequency questionnaires. All nutrient intakes were energy-adjusted by the residual method. In principal component analysis, three dietary patterns emerged. The first pattern, which was high in vitamin E, vitamin D, vitamin C, zinc, folate, total fibre, selenium and polyunsaturated fatty acids, was significantly associated with lower risk of asthenozoospermia. After adjustment for potential confounders, participants in the highest tertile of the first pattern scores had 51% lower risk of asthenozoospermia compared with those in the lowest (p-trend: .004). Our findings suggest that adherence to the pattern comprising mainly of antioxidant nutrients may be inversely associated with asthenozoospermia.
饮食营养模式与精子活力之间的关联尚未得到充分阐明，以往的研究仅关注单一营养素。本病例对照研究调查了伊朗男性中营养模式与弱精子症之间的关联。2012年1月至2013年11月期间，在伊朗德黑兰的不孕不育诊所对107例初诊弱精子症男性和235例年龄匹配的对照者进行了访谈。精液质量数据根据世界卫生组织第五版指南进行分析。基于168项半定量食物频率问卷，采用主成分分析法确定营养模式。所有营养素摄入量均采用残差法进行能量校正。在主成分分析中，出现了三种饮食模式。第一种模式富含维生素E、维生素D、维生素C、锌、叶酸、总纤维、硒和多不饱和脂肪酸，与弱精子症风险较低显著相关。在对潜在混杂因素进行校正后，第一种模式得分最高三分位数的参与者与得分最低者相比，患弱精子症的风险降低了51%（p趋势：0.004）。我们的研究结果表明，坚持主要由抗氧化营养素组成的模式可能与弱精子症呈负相关。
