基因变异与食管癌风险之间的关联。
Association between genetic variants and esophageal cancer risk.
作者信息
Yue Chenli, Li Miao, Da Chenxing, Meng Hongtao, Lv Shaomin, Zhao Xinhan
机构信息
Department of Internal Medicine Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of Respiratory Medicine, Shaanxi Provincial Crops Hospital of Chinese People's Armed Police Force, Xi'an, Shaanxi 710054, China.
出版信息
Oncotarget. 2017 Jul 18;8(29):47167-47174. doi: 10.18632/oncotarget.17006.
We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 (NAF1) and TNFAIP3-interacting protein 1 (TNIP1) gene were associated with susceptibility to esophageal cancer in a Chinese Han population. Five SNPs were genotyped and their relationship with esophageal cancer risk was analyzed in a sample of 386 esophageal cancer patients and 495 unrelated healthy controls recruited from the First Affiliated Hospital of Xi'an Jiaotong University. Patients with the AG genotype of rs2320615 were at lower risk of developing esophageal cancer than those with the GG genotype (adjusted odds ratio [OR] = 0.64, 95% confidence interval [CI] = 0.46-0.90, P = 0.009). The rs2320615 SNP was found to be associated with a decreased the risk of esophageal cancer in the dominant model (adjusted OR = 0.70, 95% CI = 0.51-0.96, P = 0.026). These results provide the first evidence that the rs2320615 in NAF1 was associated with reduced risk of esophageal cancer. Further studies with larger samples are warranted to confirm our findings.
我们研究了核组装因子1（NAF1）和肿瘤坏死因子α诱导蛋白3相互作用蛋白1（TNIP1）基因中的单核苷酸多态性（SNP）是否与中国汉族人群食管癌易感性相关。对5个SNP进行基因分型，并在西安交通大学第一附属医院招募的386例食管癌患者和495例无血缘关系的健康对照样本中分析它们与食管癌风险的关系。rs2320615的AG基因型患者患食管癌的风险低于GG基因型患者（校正比值比[OR]=0.64，95%置信区间[CI]=0.46-0.90，P=0.009）。发现rs2320615 SNP在显性模型中与食管癌风险降低相关（校正OR=0.70，95%CI=0.51-0.96，P=0.026）。这些结果首次证明NAF1中的rs2320615与食管癌风险降低相关。有必要进行更大样本量的进一步研究以证实我们的发现。
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