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极早早产的围产期实践:尽管有指南,但荷兰医生的偏好仍存在差异。

Perinatal practice in extreme premature delivery: variation in Dutch physicians' preferences despite guideline.

作者信息

Geurtzen Rosa, Draaisma Jos, Hermens Rosella, Scheepers Hubertina, Woiski Mallory, van Heijst Arno, Hogeveen Marije

机构信息

Department of Pediatrics, Radboud university medical center Amalia Children's Hospital, Nijmegen, The Netherlands.

Scientific Institute for Quality of Care, Radboud university medical center, Nijmegen, The Netherlands.

出版信息

Eur J Pediatr. 2016 Aug;175(8):1039-46. doi: 10.1007/s00431-016-2741-7. Epub 2016 Jun 1.

Abstract

UNLABELLED

Decisions at the limits of viability about initiating care are challenging. We aimed to investigate physicians' preferences on treatment decisions, against the background of the 2010 Dutch guideline offering active care from 24(+0/7) weeks of gestational age (GA). Obstetricians' and neonatologists' opinions were compared. An online survey was conducted amongst all perinatal professionals (n = 205) of the 10 Dutch level III perinatal care centers. Response rate was 60 % (n = 122). Comfort care was mostly recommended below 24(+0/7) weeks and intensive care over 26(+0/7) weeks. The professional views varied most at 24 and 25 weeks, with intensive care recommended but comfort care at parental request optional being the median. There was a wide range in perceived lowest limits of GA for interventions as a caesarian section and a neonatologist present at birth. Obstetricians and neonatologists disagreed on the lowest limit providing chest compressions and administering epinephrine for resuscitation. The main factors restricting active treatment were presence of congenital disorders, "small for gestational age" fetus, and incomplete course of corticosteroids.

CONCLUSION

There was a wide variety in individually preferred treatment decisions, especially when aspects were not covered in the Dutch guideline on perinatal practice in extreme prematurity. Furthermore, obstetricians and neonatologists did not always agree.

WHAT IS KNOWN

• Cross-cultural differences exists in the preferred treatment at the limits of viability • In the Netherlands since 2010, intensive care can be offered starting at 24 (+0/7)   weeks gestation What is new: • There was a wide variety in preferred treatment decisions at the limits of viability especially when aspects were not covered in the Dutch national guideline on perinatal practice in extreme prematurity.

摘要

未加标注

关于在可存活极限时启动治疗的决策具有挑战性。我们旨在调查医生在治疗决策上的偏好,以2010年荷兰指南为背景,该指南规定从孕龄24(+0/7)周起提供积极治疗。比较了产科医生和新生儿科医生的意见。对荷兰10家三级围产期护理中心的所有围产期专业人员(n = 205)进行了在线调查。回复率为60%(n = 122)。在24(+0/7)周以下大多建议采取舒适护理,在26(+0/7)周以上建议采取重症护理。专业意见在24周和25周时差异最大,中位数是建议采取重症护理,但应父母要求可选择舒适护理。对于剖宫产和出生时有新生儿科医生在场等干预措施,在可感知的最低孕龄极限方面存在很大差异。产科医生和新生儿科医生在进行胸外按压和给予肾上腺素进行复苏的最低极限上存在分歧。限制积极治疗的主要因素是存在先天性疾病、“小于胎龄”胎儿以及皮质类固醇疗程不完整。

结论

在个体偏好的治疗决策上存在很大差异,尤其是在荷兰关于极早产儿围产期实践的指南未涵盖某些方面时。此外,产科医生和新生儿科医生并不总是意见一致。

已知情况

• 在可存活极限时的首选治疗存在跨文化差异 • 自2010年以来,在荷兰,孕龄24(+0/7)周起可提供重症护理 新情况:• 在可存活极限时的首选治疗决策存在很大差异,尤其是在荷兰关于极早产儿围产期实践的国家指南未涵盖某些方面时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0ac/4930484/a5a7b5dcc7b6/431_2016_2741_Fig1_HTML.jpg

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