Hernández E, González S, González E
Laser Center, Dermatology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
Lasers Surg Med. 1998;23(3):167-71. doi: 10.1002/(sici)1096-9101(1998)23:3<167::aid-lsm6>3.0.co;2-n.
Current techniques for assessing local anesthetics (e.g., pin-prick test) cannot elicit a specific afferent activity without contamination from mechanosensitive receptors. This study was aimed to validate the use of non-scarring laser pulses as a reproducible method to assess effectiveness of topical anesthetics by comparing EMLA 5% cream and 40% lidocaine ointment.
STUDY DESIGN/MATERIALS AND METHODS: Thirty-two evaluations per compound were achieved in a total of eight healthy subjects. Non-scarring pulses from a 585 nm Pulsed-dye laser and a double-frequency Nd:YAG laser were investigated as pain inducers and the results were statistically analyzed by using a Student t-test.
Discrimination of anesthesia was better assessed with the 1,064 nm Nd:YAG laser. Anesthesia obtained by EMLA 5% cream was significantly higher than for 40% lidocaine ointment (P <0.0001). For EMLA cream, the number of evaluations with complete anesthesia was twice as much as for 40% lidocaine.
Non-scarring laser pulses are reliable and reproductive pain inducers for assessing topical anesthetics showing a low intra-individual variation. This technique demonstrated that EMLA 5% cream is significantly more effective than 40% lidocaine ointment.
目前用于评估局部麻醉剂的技术（如针刺试验）在不受到机械敏感受体污染的情况下，无法引发特定的传入活动。本研究旨在通过比较复方利多卡因乳膏（EMLA 5%）和40%利多卡因软膏，验证使用无瘢痕激光脉冲作为评估局部麻醉剂有效性的可重复方法。
研究设计/材料与方法：在总共8名健康受试者中，每种化合物进行了32次评估。研究了来自585nm脉冲染料激光和倍频Nd:YAG激光的无瘢痕脉冲作为疼痛诱导源，并使用学生t检验对结果进行统计分析。
使用1064nm Nd:YAG激光能更好地评估麻醉辨别情况。复方利多卡因乳膏（EMLA 5%）产生的麻醉效果显著高于40%利多卡因软膏（P<0.0001）。对于复方利多卡因乳膏，完全麻醉的评估次数是40%利多卡因的两倍。
无瘢痕激光脉冲是评估局部麻醉剂的可靠且可重复的疼痛诱导源，个体内差异较小。该技术表明复方利多卡因乳膏（EMLA 5%）比40%利多卡因软膏显著更有效。
