Gualdi Giulio, Monari Paola, Pelizzari Laura, Cammalleri Daniele, Calzavara-Pinton Piergiacomo
Department of Dermatology, A.O. Spedali Civili, University of Brescia, Brescia, Italy.
Plast Reconstr Surg Glob Open. 2016 Mar 7;4(3):e633. doi: 10.1097/GOX.0000000000000595. eCollection 2016 Mar.
The "nested graft" is an innovative and well-defined surgical technique used for chronic wound healing that induces the de-senescence of fibroblasts in the wound bed. We report a case of a 76-year-old man affected by plantar chronic wounds because of acral lichen sclerosus and atrophicus localized at both feet and treated for many years successfully with immunosuppressive agents. For cardiological dysfunction, systemic therapy was reduced to low dosage of steroids with an increase of ulcerations (5 × 2 cm). So we decided to perform the nested graft on the plantar region. After the surgical procedure, all the grafted ulcers healed, and at a 4-month follow-up, no signs of lichen sclerosus were present.
“嵌套移植”是一种创新且明确的外科技术，用于慢性伤口愈合，可诱导伤口床中的成纤维细胞去衰老。我们报告了一例76岁男性，因双足局限性肢端硬皮病和萎缩性苔藓而患有足底慢性伤口，多年来一直用免疫抑制剂成功治疗。由于心脏功能障碍，全身治疗减至低剂量类固醇，溃疡增多（5×2厘米）。因此，我们决定在足底区域进行嵌套移植。手术后，所有移植的溃疡均愈合，在4个月的随访中，未见硬皮病迹象。
