Greenhouse Ian, Noah Sean, Maddock Richard J, Ivry Richard B
University of California, Berkeley, Berkeley, CA, United States.
University of California, Berkeley, Berkeley, CA, United States.
Neuroimage. 2016 Oct 1;139:1-7. doi: 10.1016/j.neuroimage.2016.06.007. Epub 2016 Jun 9.
H magnetic resonance spectroscopy (MRS) provides a powerful tool to measure gamma-aminobutyric acid (GABA), the principle inhibitory neurotransmitter in the human brain. We asked whether individual differences in MRS estimates of GABA are uniform across the cortex or vary between regions. In two sessions, resting GABA concentrations in the lateral prefrontal, sensorimotor, dorsal premotor, and occipital cortices were measured in twenty-eight healthy individuals. GABA estimates within each region were stable across weeks, with low coefficients of variation. Despite this stability, the GABA estimates were not correlated between regions. In contrast, the percentage of brain tissue per volume, a control measure, was correlated between the three anterior regions. These results provide an interesting dissociation between an anatomical measure of individual differences and a neurochemical measure. The different patterns of anatomy and GABA concentrations have implications for understanding regional variation in the molecular topography of the brain in health and disease.
氢磁共振波谱（MRS）提供了一种强大的工具来测量γ-氨基丁酸（GABA），它是人类大脑中的主要抑制性神经递质。我们研究了MRS对GABA估计值的个体差异在整个皮层中是否一致，还是在不同区域之间存在变化。在两个阶段中，对28名健康个体的外侧前额叶、感觉运动、背侧运动前区和枕叶皮层的静息GABA浓度进行了测量。每个区域内的GABA估计值在数周内保持稳定，变异系数较低。尽管具有这种稳定性，但不同区域之间的GABA估计值并无相关性。相比之下，作为对照指标的每体积脑组织百分比在三个前部区域之间具有相关性。这些结果揭示了个体差异的解剖学测量与神经化学测量之间有趣的分离。解剖结构和GABA浓度的不同模式对于理解健康和疾病状态下大脑分子拓扑结构的区域差异具有重要意义。
