用于模拟肿瘤微环境中巨噬细胞与细胞外基质相互作用的生物材料方法。
Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment.
作者信息
Springer Nora L, Fischbach Claudia
机构信息
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Comparative Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Comparative Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA; Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, NY 14853, USA.
出版信息
Curr Opin Biotechnol. 2016 Aug;40:16-23. doi: 10.1016/j.copbio.2016.02.003. Epub 2016 Feb 25.
Tumors are characterized by aberrant extracellular matrix (ECM) remodeling and chronic inflammation. While advances in biomaterials and tissue engineering strategies have led to important new insights regarding the role of ECM composition, structure, and mechanical properties in cancer in general, the functional link between these parameters and macrophage phenotype is poorly understood. Nevertheless, increasing experimental evidence suggests that macrophage behavior is similarly controlled by physicochemical properties of the ECM and consequential changes in mechanosignaling. Here, we will summarize the current knowledge of macrophage biology and ECM-mediated differences in mechanotransduction and discuss future opportunities of biomaterials and tissue engineering platforms to interrogate the functional relationship between these parameters and their relevance to cancer.
肿瘤的特征是细胞外基质（ECM）异常重塑和慢性炎症。虽然生物材料和组织工程策略的进展已就ECM组成、结构和力学性能在癌症中的作用带来了重要的新见解，但这些参数与巨噬细胞表型之间的功能联系仍知之甚少。然而，越来越多的实验证据表明，巨噬细胞行为同样受ECM的物理化学性质以及机械信号传导的相应变化所控制。在此，我们将总结巨噬细胞生物学的现有知识以及ECM介导的机械转导差异，并讨论生物材料和组织工程平台在探究这些参数之间的功能关系及其与癌症相关性方面的未来机遇。
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