迈向螺旋膜蛋白结构与功能的高分辨率计算设计
Toward high-resolution computational design of the structure and function of helical membrane proteins.
作者信息
Barth Patrick, Senes Alessandro
机构信息
Structural and Computational Biology and Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, Texas, USA.
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Nat Struct Mol Biol. 2016 Jun 7;23(6):475-80. doi: 10.1038/nsmb.3231.
Abstract
The computational design of α-helical membrane proteins is still in its infancy but has already made great progress. De novo design allows stable, specific and active minimal oligomeric systems to be obtained. Computational reengineering can improve the stability and function of naturally occurring membrane proteins. Currently, the major hurdle for the field is the experimental characterization of the designs. The emergence of new structural methods for membrane proteins will accelerate progress.
摘要
α-螺旋膜蛋白的计算设计仍处于起步阶段，但已取得了巨大进展。从头设计能够获得稳定、特异且具有活性的最小寡聚体系统。计算改造可提高天然存在的膜蛋白的稳定性和功能。目前，该领域的主要障碍是对设计进行实验表征。膜蛋白新结构方法的出现将加速进展。
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