• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氢气作为一种有前景的治疗眼部疾病的策略的潜在应用。

The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.

作者信息

Tao Ye, Geng Lei, Xu Wei-Wei, Qin Li-Min, Peng Guang-Hua, Huang Yi-Fei

机构信息

Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.

Department of Orthopaedics, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.

出版信息

Ther Clin Risk Manag. 2016 May 19;12:799-806. doi: 10.2147/TCRM.S102518. eCollection 2016.

DOI:10.2147/TCRM.S102518
PMID:27279745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4878665/
Abstract

Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-related diseases, including the transplantation-induced intestinal graft injury, chronic inflammation, ischemia-reperfusion injuries, and so on. Especially in the eye, hydrogen has been used to counteract multiple ocular pathologies in the ophthalmological models. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed. It is our hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich our pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases.

摘要

氢气是最知名的天然分子之一，由于其能够选择性地中和细胞毒性活性氧并减轻有害炎症，已被应用于众多医学领域。氢气可以对各种与活性氧相关的疾病发挥保护作用，包括移植引起的肠道移植损伤、慢性炎症、缺血再灌注损伤等。特别是在眼部，氢气已被用于眼科模型中对抗多种眼部疾病。本文系统综述了氢气在眼科方面的应用，并探讨了氢气产生有益作用的潜在机制。我们希望，这些开创性研究所证明的氢气的保护作用，将丰富我们对这种天然元素的药理学认识，并为发现一种针对眼部疾病的新型治疗策略提供线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f044/4878665/09262838c094/tcrm-12-799Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f044/4878665/e99c0a59abd3/tcrm-12-799Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f044/4878665/09262838c094/tcrm-12-799Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f044/4878665/e99c0a59abd3/tcrm-12-799Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f044/4878665/09262838c094/tcrm-12-799Fig2.jpg

相似文献

1
The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.氢气作为一种有前景的治疗眼部疾病的策略的潜在应用。
Ther Clin Risk Manag. 2016 May 19;12:799-806. doi: 10.2147/TCRM.S102518. eCollection 2016.
2
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.通过快速扩散氢气来保护视网膜：在视网膜缺血再灌注损伤中给予含氢眼药水。
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):487-92. doi: 10.1167/iovs.09-4089. Epub 2009 Oct 15.
3
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw.富氢盐水可能是一种治疗颌骨放射性骨坏死的有效且特异的新型疗法。
Ther Clin Risk Manag. 2015 Oct 14;11:1581-5. doi: 10.2147/TCRM.S90770. eCollection 2015.
4
Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.富氢盐水作为白内障的创新疗法：一种假说。
Med Sci Monit. 2016 Sep 8;22:3191-5. doi: 10.12659/msm.899807.
5
Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death.氢气吸入对心脏死亡供体大鼠在热缺血期对肺缺血再灌注损伤的保护作用。
Microvasc Res. 2019 Sep;125:103885. doi: 10.1016/j.mvr.2019.103885. Epub 2019 Jun 5.
6
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.乳果糖通过激活 Nrf2 表达诱导氢气来减轻大鼠脑缺血再灌注损伤。
Free Radic Biol Med. 2013 Dec;65:731-741. doi: 10.1016/j.freeradbiomed.2013.08.004. Epub 2013 Aug 13.
7
Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models.单次氢气预处理不能减轻大鼠皮瓣缺血再灌注损伤。
J Plast Reconstr Aesthet Surg. 2019 Oct;72(10):1661-1668. doi: 10.1016/j.bjps.2019.06.006. Epub 2019 Jul 5.
8
Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway.硫化氢通过Keap1的巯基化、丝裂原活化蛋白激酶（MAPK）依赖性抗凋亡和核因子κB（NF-κB）依赖性抗炎途径保护胃上皮细胞免受缺血/再灌注损伤。
Eur J Pharmacol. 2014 Feb 15;725:70-8. doi: 10.1016/j.ejphar.2014.01.009. Epub 2014 Jan 18.
9
Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma.眼前节活性氧的产生。N-乙酰肌肽润滑眼药水与线粒体靶向抗氧化剂的协同共药作为治疗白内障和原发性开角型青光眼的强大治疗平台。
BBA Clin. 2016 Apr 19;6:49-68. doi: 10.1016/j.bbacli.2016.04.004. eCollection 2016 Dec.
10
Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.富氢的威斯康星大学溶液减轻肾脏冷缺血再灌注损伤。
Transplantation. 2012 Jul 15;94(1):14-21. doi: 10.1097/TP.0b013e318255f8be.

引用本文的文献

1
Beneficial Effect of Sirolimus-Pretreated Mesenchymal Stem Cell Implantation on Diabetic Retinopathy in Rats.西罗莫司预处理的间充质干细胞植入对大鼠糖尿病视网膜病变的有益作用
Biomedicines. 2024 Feb 7;12(2):383. doi: 10.3390/biomedicines12020383.
2
Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?分子氢的新作用：眼科疾病的终结？
Pharmaceuticals (Basel). 2023 Nov 7;16(11):1567. doi: 10.3390/ph16111567.
3
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.

本文引用的文献

1
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.分子氢的有益生物学效应及其潜在机制——321篇原创文章的综合综述
Med Gas Res. 2015 Oct 19;5:12. doi: 10.1186/s13618-015-0035-1. eCollection 2015.
2
Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury.富氢盐水通过抑制视网膜缺血再灌注损伤中的DNA氧化应激和聚（ADP-核糖）聚合酶-1的过度激活来减少细胞死亡。
Mol Med Rep. 2015 Aug;12(2):2495-502. doi: 10.3892/mmr.2015.3731. Epub 2015 May 5.
3
分子氢通过上调抗凋亡途径减轻 N-甲基-N-亚硝脲诱导的角膜内皮损伤。
Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):2. doi: 10.1167/iovs.62.9.2.
4
Micro/nanodevices for assessment and treatment in stomatology and ophthalmology.用于口腔和眼科评估与治疗的微/纳米器件
Microsyst Nanoeng. 2021 Jan 29;7:11. doi: 10.1038/s41378-021-00238-1. eCollection 2021.
5
Oxidative stress-induced RAC autophagy can improve the HUVEC functions by releasing exosomes.氧化应激诱导的 RAC 自噬通过释放外泌体可以改善 HUVEC 的功能。
J Cell Physiol. 2020 Oct;235(10):7392-7409. doi: 10.1002/jcp.29641. Epub 2020 Feb 24.
6
Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage.分子氢治疗角膜 UVB 诱导的氧化应激和光损伤的疗效。
Sci Rep. 2017 Dec 21;7(1):18017. doi: 10.1038/s41598-017-18334-6.
7
The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against -Methyl--Nitrosourea Induced Retinal Degeneration: A Topographic Study.腹腔内和玻璃体内注射富氢盐水对甲基亚硝基脲诱导的视网膜变性的比较效果：一项地形图研究。
Front Pharmacol. 2017 Aug 29;8:587. doi: 10.3389/fphar.2017.00587. eCollection 2017.
8
Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.富氢盐水作为白内障的创新疗法：一种假说。
Med Sci Monit. 2016 Sep 8;22:3191-5. doi: 10.12659/msm.899807.
Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats.
富氢盐水可预防大鼠瑞芬太尼诱导的痛觉过敏，并通过调节含NR2B的NMDA受体抑制锰超氧化物歧化酶硝化。
Neuroscience. 2014 Nov 7;280:171-80. doi: 10.1016/j.neuroscience.2014.09.024. Epub 2014 Sep 18.
4
Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.静脉输注富氢液联合脑池内注射硫酸镁治疗重症动脉瘤性蛛网膜下腔出血的效果：一项随机对照试验的研究方案
BMC Neurol. 2014 Sep 9;14:176. doi: 10.1186/s12883-014-0176-1.
5
Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.富氢盐水可促进视神经挤压大鼠模型中视网膜神经节细胞的存活。
PLoS One. 2014 Jun 10;9(6):e99299. doi: 10.1371/journal.pone.0099299. eCollection 2014.
6
Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats.鞘内输注富氢生理盐水通过抑制脊髓星形胶质细胞和小胶质细胞的激活减轻大鼠的神经病理性疼痛。
PLoS One. 2014 May 23;9(5):e97436. doi: 10.1371/journal.pone.0097436. eCollection 2014.
7
Hydrogen-rich saline ameliorates the retina against light-induced damage in rats.富氢盐水可改善大鼠视网膜免受光诱导损伤。
Med Gas Res. 2013 Sep 1;3(1):19. doi: 10.1186/2045-9912-3-19.
8
Hydrogen saline prevents selenite-induced cataract in rats.氢生理盐水可预防大鼠亚硒酸盐诱导的白内障。
Mol Vis. 2013 Jul 29;19:1684-93. Print 2013.
9
Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.分子氢调节脂多糖激活的视网膜小胶质细胞中miR-9、miR-21和miR-199的表达。
Int J Ophthalmol. 2013 Jun 18;6(3):280-5. doi: 10.3980/j.issn.2222-3959.2013.03.05. Print 2013.
10
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.经腹膜给予溶解氢用于腹膜透析患者：一种抑制腹膜腔氧化应激的新方法。
Med Gas Res. 2013 Jul 1;3(1):14. doi: 10.1186/2045-9912-3-14.