Sakanaka S, Shimura N, Aizawa M, Kim M, Yamamoto T
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.
b Department of Preventive Dentistry , Tokyo Medical and Dental University, Yushima, Bunkyo-ku , Tokyo 113 , Japan.
Biosci Biotechnol Biochem. 1992 Jan;56(4):592-4. doi: 10.1271/bbb.56.592.
The effects of green tea polyphenols, inhibitors of various biological activities of cariogenic bacteria in vitro, on caries development were examined using conventional rats. A total of 96 male rats were divided into 8 groups and the rats in the test groups were given tea polyphenols ranging from 0.1% to 0.5% in their cariogenic diet or drinking water for 40 days. Total fissure caries lesions was significantly reduced by the addition of tea polyphenols to the diet or in the drinking water. Diet containing 0.1% tea polyphenols demonstrated about 40% reduction of total fissure caries lesions. No toxic effect of tea polyphenols on rats were observed under these experimental conditions.
利用常规大鼠研究了绿茶多酚（在体外对致龋菌的各种生物活性具有抑制作用）对龋齿发展的影响。总共96只雄性大鼠被分为8组，给试验组大鼠在其致龋饮食或饮用水中添加0.1%至0.5%的茶多酚，持续40天。在饮食或饮用水中添加茶多酚可显著减少总的窝沟龋损。含0.1%茶多酚的饮食使总的窝沟龋损减少了约40%。在这些实验条件下未观察到茶多酚对大鼠有任何毒性作用。
