Yokozawa T, Oura H, Sakanaka S, Kim M
a Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University , Sugitani, Toyama 930-01 , Japan.
b Central Research Laboratories, Taiyo Kagaku Co., Ltd ., Yokkaichi, Mie 510 , Japan.
Biosci Biotechnol Biochem. 1992 Jan;56(6):896-9. doi: 10.1271/bbb.56.896.
The hydroxyl radical scavenging action of green tea tannin given orally to rats with experimental renal failure was examined by using the urinary methylguanidine excretion as an index. In rats given 2 mg of a green tea tannin mixture, the urinary methylguanidine excretion was significantly decreased or had a tendency to decrease. (-)-Epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, effected a decrease in the urinary methylguanidine excretion in rats at a dose as low as 0.25 mg, suggesting a hydroxyl radical scavenging action.
以尿甲基胍排泄量为指标，研究了口服绿茶单宁对实验性肾衰竭大鼠的羟自由基清除作用。给予2毫克绿茶单宁混合物的大鼠，尿甲基胍排泄量显著降低或有降低趋势。绿茶单宁混合物的主要成分（-）-表没食子儿茶素3-O-没食子酸酯，在低至0.25毫克的剂量下就能使大鼠尿甲基胍排泄量降低，表明其具有羟自由基清除作用。
