Sharples E J, Mittal S M, Friend P J
Oxford Transplant Centre, Churchill Hospital, Oxford University Hospitals, Old Road, Headington, Oxford, OX3 7LE, UK.
Nuffield Department of Surgery, Oxford University, Oxford, UK.
Acta Diabetol. 2016 Dec;53(6):871-878. doi: 10.1007/s00592-016-0865-x. Epub 2016 Jun 10.
Whole-organ pancreas transplantation, either alone or combined with a kidney transplant, is the only definitive treatment for many patients with type 1 diabetes that restores normal glucose homoeostasis and insulin independence. Pancreas transplantation delays, or potentially prevents, secondary diabetes complications and is associated with improvement in patient survival when compared with either patients remaining on the waiting list or those receiving kidney transplant alone. Pancreas transplantation is safe and effective, with 1-year patient survival >97 % and graft survival rates of 85 % at 1 year and 76 % at 5 years in recent UK data. This review focuses on some current areas of interest in pancreas transplantation.
全胰腺移植，无论是单独进行还是与肾移植联合进行，对于许多1型糖尿病患者而言都是唯一能恢复正常血糖稳态并实现胰岛素自主分泌的确定性治疗方法。与仍在等待名单上的患者或仅接受肾移植的患者相比，胰腺移植可延缓或潜在预防继发性糖尿病并发症，并与患者生存率的提高相关。胰腺移植是安全有效的，近期英国数据显示，患者1年生存率>97%，移植物1年生存率为85%，5年生存率为76%。本综述重点关注胰腺移植当前一些受关注的领域。
