Wang Tie, Tian Lining, Gao Meizhuo, Song Hongjiang, Wei Yuzhe, Xue Yingwei
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Department of Medical Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Ann Med Surg (Lond). 2016 May 18;9:1-5. doi: 10.1016/j.amsu.2016.05.011. eCollection 2016 Aug.
Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and gastric cancer has been studied in different populations with inconsistent results. Here, we report this meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC susceptibility in both Asian and Caucasian populations.
胃癌（GC）是一种影响全球患者的常见癌症。胃癌的发病机制尚未完全明确。基因突变以及幽门螺杆菌（HP）诱导的炎症似乎起着重要作用。细胞因子白细胞介素-4（IL-4）在炎症、过敏和包括胃癌在内的癌症中发挥作用。已在不同人群中研究了IL-4 -590 C>T多态性与胃癌的关联，结果并不一致。在此，我们报告这项荟萃分析，表明IL-4 -590C>T多态性在亚洲和白种人群体中可能与胃癌易感性无关。
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