植物酚类与自噬

Plant Phenols and Autophagy.

作者信息

Zenkov N K, Chechushkov A V, Kozhin P M, Kandalintseva N V, Martinovich G G, Menshchikova E B

机构信息

Research Institute of Experimental and Clinical Medicine, Novosibirsk, 630117, Russia.

出版信息

Biochemistry (Mosc). 2016 Apr;81(4):297-314. doi: 10.1134/S0006297916040015.

DOI:10.1134/S0006297916040015

PMID:27293088

Abstract

Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical studies on the potential of phenolic compounds for treatment of cardiovascular, neurodegenerative, oncological, and inflammatory diseases are now being conducted. In addition to direct antioxidant effect, plant phenols may provide a protective effect via activation of the Keap1/Nrf2/ARE redox-sensitive signaling system and regulation of autophagy. In this review, mechanisms of effects of the most common plant phenols on autophagy are presented.

摘要

许多植物酚类物质（如芪类、姜黄素、儿茶素、黄酮类等）是有效的抗氧化剂，可在氧化应激期间保护细胞。目前正在对酚类化合物治疗心血管疾病、神经退行性疾病、肿瘤疾病和炎症性疾病的潜力进行广泛的临床研究。除了直接的抗氧化作用外，植物酚类物质还可通过激活Keap1/Nrf2/ARE氧化还原敏感信号系统和调节自噬来提供保护作用。在这篇综述中，介绍了最常见的植物酚类物质对自噬的作用机制。