Thomas Guillaume, Demoisson Frédéric, Boudon Julien, Millot Nadine
Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 CNRS-Université Bourgogne Franche-Comté, 9 Av. A. Savary, BP 47870 F-21078 DIJON Cedex, France.
Dalton Trans. 2016 Jun 28;45(26):10821-9. doi: 10.1039/c6dt01050d.
For the first time, phosphonate-functionalized magnetite nanoparticles (Fe3O4 NPs) were synthesized using a one-step continuous hydrothermal process. The NP surface was modified using a hydrophilic organic molecule, namely 6-phosphonohexanoic acid (PHA). NPs were fully characterized (TEM, XRD, DLS, ζ-potential, TGA, FTIR, XPS and specific surface area measurements) in order to investigate PHA effect on size, oxidation state, anchoring and colloidal stability. PHA reduced the crystallite size and size distribution and improved greatly colloidal stability when compared with bare Fe3O4 NPs. Moreover, PHA was grafted on the NP surface according to three different conformations: as mononuclear monodendates, as binuclear bidentates or as lying-down complexes. This report is very promising regarding the stabilization and functionalization of Fe3O4 NPs by phosphonate molecules under continuous hydrothermal conditions. The post-grafting of polymers such as polyethylene glycol can be considered owing to the presence of free carboxyl groups (-COOH) on the surface of Fe3O4 NPs.
首次采用一步连续水热法合成了膦酸官能化的磁铁矿纳米颗粒（Fe3O4 NPs）。使用亲水性有机分子6-膦酰基己酸（PHA）对NP表面进行修饰。对NP进行了全面表征（透射电子显微镜、X射线衍射、动态光散射、ζ电位、热重分析、傅里叶变换红外光谱、X射线光电子能谱和比表面积测量），以研究PHA对尺寸、氧化态、锚固和胶体稳定性的影响。与裸Fe3O4 NPs相比，PHA减小了微晶尺寸和尺寸分布，并大大提高了胶体稳定性。此外，PHA以三种不同构象接枝在NP表面：作为单核单齿、双核双齿或平躺配合物。该报告对于在连续水热条件下通过膦酸分子对Fe3O4 NPs进行稳定化和功能化非常有前景。由于Fe3O4 NPs表面存在游离羧基（-COOH），可以考虑接枝聚乙二醇等聚合物。
