Song Jia-Ling, Yuan Yao, Tan Hai-Bo, Huang Ri-Ming, Liu Hong-Xin, Xu Zhi-Fang, Qiu Sheng-Xiang
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
b University of Chinese Academy of Sciences , Beijing 100049 , China.
J Asian Nat Prod Res. 2017 Mar;19(3):222-228. doi: 10.1080/10286020.2016.1191474. Epub 2016 Jun 14.
Two new coumarins, named (±)-euryacoumarin A (1) and 6-demethylobtusinin (2), and one new natural coumarin, named euryacoumarin B (3), along with two known compounds, scopoletin (4) and obtusinol (5), were isolated from the stems of Eurya chinensis. Their structures were elucidated by means of extensive spectroscopic methods and comparison with data reported in the literatures. Compound 1 exhibited significant inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC value of 35.64 ± 1.73 μM, and showed marginal antibacterial activities against Bacillus subtilis and B. cereus with MIC values of 50.59 ± 2.12 and 35.42 ± 0.96 μM, respectively.
从中华柃木茎中分离得到两个新的香豆素，分别命名为(±)-柃木香豆素A（1）和6-去甲基 obtusinin（2），以及一个新的天然香豆素，命名为柃木香豆素B（3），同时还得到两个已知化合物，东莨菪素（4）和 obtusinol（5）。通过广泛的光谱方法并与文献报道的数据进行比较，阐明了它们的结构。化合物1对RAW264.7细胞中脂多糖诱导的一氧化氮（NO）产生具有显著抑制作用，IC值为35.64±1.73μM，并且对枯草芽孢杆菌和蜡样芽孢杆菌显示出微弱的抗菌活性，MIC值分别为50.59±2.12和35.42±0.96μM。
