Vogel S B, Woodward E R
Department of Surgery, University of Florida, College of Medicine, Gainesville 32610.
Ann Surg. 1989 Jun;209(6):756-61; discussion 761-3. doi: 10.1097/00000658-198906000-00013.
Symptoms of severe nausea, vomiting, abdominal pain, and frequent bezoars, as well as objective gastric retention, can occur following Roux-Y biliary diversion for alkaline reflux gastritis. Medical therapy and prokinetic drugs have proven ineffective. This review evaluates 37 patients who underwent further gastric resection from 1979 to 1987 to improve gastric emptying and resolve symptoms. Fifteen patients underwent perioperative radionuclide solid-food gastric emptying studies. Seventy-three per cent (27 of 37 patients) of the patients who underwent further gastric resection (70% to 95%) had a satisfactory postoperative response. Twenty patients were graded Visick 1 or 2 and 7 Visick-3 patients, although much improved, still had some symptoms of gastroparesis. Twenty-seven per cent (10 of 37 patients) failed to improve and underwent completion total gastrectomy. Overall, 70% of this group had almost complete resolution of their symptoms. Three of 10 patients were considered "failures" due to postprandial pain in 1 and early vasomotor dumping in 2. Of the 10 patients who failed initial revisional surgery, 7 underwent a 70% to 80% subtotal gastric resection (STG) and 3 patients underwent 85% to 95% extensive resection (EXT.G.). Of the 15 patients who underwent perioperative radionuclide evaluation, a mean two-hour gastric retention of 61.4% +/- 4% (SEM) decreased to 25% +/- 4% following further gastric resection. Eight patients were in the STG group and seven patients were in the EXT.G group. Following STG, mean two-hour gastric retention of 58.2% +/- 3.5% decreased to 38% +/- 3% (p less than 0.05). In seven patients who underwent EXT.G, mean two-hour retention of 65% +/- 4% decreased to 10% +/- 2.5% (p less than 0.005). EXT.G resulted in normal gastric emptying and few late failures. In post-Roux-Y patients with symptoms of gastroparesis and documented gastric retention, EXT.G normalizes gastric emptying and restores a better quality of life. Total gastrectomy should be reserved for those patients who are failed by more extensive resection.
在因碱性反流性胃炎行Roux-Y胆肠分流术后,可能会出现严重恶心、呕吐、腹痛、频繁出现胃石以及客观存在的胃潴留症状。药物治疗和促动力药物已被证明无效。本综述评估了1979年至1987年间接受进一步胃切除术以改善胃排空和缓解症状的37例患者。15例患者进行了围手术期放射性核素固体食物胃排空研究。接受进一步胃切除术的患者中,73%(37例中的27例)术后反应良好(切除范围为70%至95%)。20例患者Visick分级为1级或2级,7例Visick-3级患者虽然有很大改善,但仍有一些胃轻瘫症状。27%(37例中的10例)患者病情未改善,接受了全胃切除术。总体而言,该组70%的患者症状几乎完全缓解。10例患者中有3例被视为“失败者”,其中1例因餐后疼痛,2例因早期血管运动性倾倒。在最初翻修手术失败的10例患者中,7例接受了70%至80%的胃次全切除术(STG),3例患者接受了85%至95%的广泛切除术(EXT.G.)。在接受围手术期放射性核素评估的15例患者中,进一步胃切除术后平均两小时胃潴留率从61.4%±4%(SEM)降至25%±4%。8例患者在STG组,7例患者在EXT.G组。STG术后,平均两小时胃潴留率从58.2%±3.5%降至38%±3%(p<0.05)。在7例接受EXT.G的患者中,平均两小时潴留率从65%±4%降至10%±2.5%(p<0.005)。EXT.G可使胃排空正常化且很少出现晚期失败情况。在Roux-Y术后有胃轻瘫症状且有胃潴留记录的患者中,EXT.G可使胃排空正常化并恢复更好的生活质量。全胃切除术应仅用于那些经更广泛切除手术失败的患者。