Ataie Amin, Shadifar Mohammad, Ataee Ramin
Cellular and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran.
Amol Center, Pasteur Institute of Iran, Amol, Iran.
Basic Clin Neurosci. 2016 Apr;7(2):81-90. doi: 10.15412/J.BCN.03070201.
Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical journals and academic informations' sites. According to many studies, antioxidants could reduce toxic neuronal damages and many studies confirmed the efficacy of polyphenol antioxidants in fruits and vegetables to reduce neuronal death and to diminish oxidative stress. This systematic review showed the antioxidant activities of phytochemicals which play as natural neuroprotectives with low adverse effects against some neurodegenerative diseases as Parkinson or Alzheimer diseases.
许多研究表明，氧化应激参与神经退行性疾病的病理生理过程。氧化应激可诱导神经元损伤，调节细胞内信号传导，并最终通过凋亡或坏死导致神经元死亡。为了综述抗氧化剂对氧化应激和神经退行性疾病的预防作用，我们从国际医学期刊和学术信息网站收集了数据。根据许多研究，抗氧化剂可以减少有毒的神经元损伤，许多研究证实了水果和蔬菜中多酚类抗氧化剂在减少神经元死亡和减轻氧化应激方面的功效。这项系统综述显示了植物化学物质的抗氧化活性，这些植物化学物质作为天然神经保护剂，对帕金森病或阿尔茨海默病等一些神经退行性疾病具有低不良反应。
