Budanov Andrei V
Department of Human and Molecular Genetics; Goodwin Research Laboratories; Massey Cancer Center; Virginia Commonwealth University ; Richmond, VA, USA.
Mol Cell Oncol. 2015 Jan 23;2(3):e997113. doi: 10.1080/23723556.2014.997113. eCollection 2015 Jul-Sep.
SESTRINs, proteins encoded by the SESN1-3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent studies support the RRAGA/B-dependence of mTORC1 regulation by SESTRINs; however, the role of GATOR2 in this process requires clarification.
SESTRINs是哺乳动物中由SESN1 - 3基因编码的蛋白质，是雷帕霉素复合物1（mTORC1）激酶机制靶点的成熟抑制因子。最近，我们发现SESTRINs与GATOR2蛋白复合物结合，GATOR2蛋白复合物是RRAGA/B鸟苷三磷酸酶的调节因子。三项独立研究支持SESTRINs对mTORC1调节的RRAGA/B依赖性；然而，GATOR2在此过程中的作用需要阐明。
