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氯喹的抗癌活性是由对肿瘤脉管系统的自噬非依赖性作用介导的。

Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature.

作者信息

Maes Hannelore, Kuchnio Anna, Carmeliet Peter, Agostinis Patrizia

机构信息

Department Cellular and Molecular Medicine; Laboratory of Cell Death and Therapy ; KU Leuven, Leuven, Belgium.

Department of Oncology; Laboratory of Angiogenesis and Neurovascular Link; KU Leuven, Leuven, Belgium; Vesalius Research Center; Laboratory of Angiogenesis and Neurovascular Link; VIB, Leuven, Belgium.

出版信息

Mol Cell Oncol. 2015 Dec 9;3(1):e970097. doi: 10.4161/23723548.2014.970097. eCollection 2016 Jan.

DOI:10.4161/23723548.2014.970097
PMID:27308577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845249/
Abstract

Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-independent, NOTCH1-reliant mechanism of tumor vessel normalization.

摘要

氯喹在临床上用作自噬阻断剂以增强抗癌治疗效果。然而，氯喹是否仅通过自噬依赖性和癌细胞自主机制发挥作用仍不清楚。在最近的一项研究中，我们发现氯喹可降低肿瘤内缺氧和转移，同时改善化疗反应，这主要是通过一种不依赖自噬、依赖NOTCH1的肿瘤血管正常化机制实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d17/4845249/6756e34a5d61/kmco-03-01-970097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d17/4845249/6756e34a5d61/kmco-03-01-970097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d17/4845249/6756e34a5d61/kmco-03-01-970097-g001.jpg

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2
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Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):761-8. doi: 10.1016/j.ijrobp.2013.07.024.
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Autophagy: shaping the tumor microenvironment and therapeutic response.自噬：塑造肿瘤微环境和治疗反应。
血心屏障渗漏机制：对 COVID-19 引起的心血管损伤的影响。
Int J Mol Sci. 2021 Dec 17;22(24):13546. doi: 10.3390/ijms222413546.
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Vascular Normalization: A New Window Opened for Cancer Therapies.血管正常化：为癌症治疗打开的一扇新窗口。
Front Oncol. 2021 Aug 12;11:719836. doi: 10.3389/fonc.2021.719836. eCollection 2021.
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