Peyre Marisa, Choisy Marc, Sobhy Heba, Kilany Walid H, Gély Marie, Tripodi Astrid, Dauphin Gwenaëlle, Saad Mona, Roger François, Lubroth Juan, Jobre Yilma
A UPR AGRIS, Centre International de Recherche en Agriculture pour le Développement, 34398, Montpellier, France.
B UMR MIVEGEC, 34394, Montpellier, France; Oxford University Clinical Research Unit (OUCRU), Hanoi, Vietnam.
Avian Dis. 2016 May;60(1 Suppl):245-52. doi: 10.1637/11131-050715-ResNote.
The immunity profile against H5N1 highly pathogenic avian influenza (HPAI) in the commercial poultry value chain network in Egypt was modeled with the use of different vaccination scenarios. The model estimated the vaccination coverage, the protective seroconversion level, and the duration of immunity for each node of the network and vaccination scenario. Partial budget analysis was used to compare the benefit-cost of the different vaccination scenarios. The model predicted that targeting day-old chick avian influenza (AI) vaccination in industrial and large hatcheries would increase immunity levels in the overall poultry population in Egypt and especially in small commercial poultry farms (from <30% to >60%). This strategy was shown to be more efficient than the current strategy of using inactivated vaccines. Improving HPAI control in the commercial poultry sector in Egypt would have a positive impact to improve disease control.
利用不同的疫苗接种方案对埃及商业家禽价值链网络中针对H5N1高致病性禽流感（HPAI）的免疫情况进行了建模。该模型估计了网络中每个节点以及接种方案的疫苗接种覆盖率、保护性血清转化水平和免疫持续时间。采用部分预算分析来比较不同接种方案的效益成本。该模型预测，针对工业和大型孵化场的一日龄雏鸡进行禽流感（AI）疫苗接种，将提高埃及家禽总体的免疫水平，特别是小型商业家禽养殖场的免疫水平（从<30%提高到>60%）。结果表明，这一策略比目前使用灭活疫苗的策略更有效。改善埃及商业家禽部门的高致病性禽流感防控将对改善疾病控制产生积极影响。
