乙酰肝素酶为外泌体产生定制多配体蛋白聚糖。
Heparanase tailors syndecan for exosome production.
作者信息
David Guido, Zimmermann Pascale
机构信息
Laboratory for Glycobiology and Developmental Genetics, Department of Human Genetics, KU Leuven , Leuven, Belgium.
Laboratory for Signal Integration in Cell Fate Decision, Department of Human Genetics, KU Leuven, Leuven, Belgium; Centre de Recherche en Cancérologie de Marseille (CRCM), Aix-Marseille Université, Marseille, F-13284, France, Inserm, U1068, Institut Paoli-Calmettes, CNRS, UMR7258, Marseille, France.
出版信息
Mol Cell Oncol. 2015 Nov 11;3(3):e1047556. doi: 10.1080/23723556.2015.1047556. eCollection 2016 May.
Abstract
Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these vesicles depends on syntenin and syndecans. Heparanase acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology.
摘要
外泌体是参与信号传导过程的分泌性囊泡。这类囊泡中的一类的生物发生依赖于 syntenin 和 syndecan。乙酰肝素酶作为 syndecan-syntenin-外泌体生物发生途径的调节因子。癌症中 syntenin 和乙酰肝素酶的上调可能支持外泌体在肿瘤生物学中所怀疑的作用。
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本文引用的文献
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Heparanase activates the syndecan-syntenin-ALIX exosome pathway.乙酰肝素酶激活Syndecan- syntenin-ALIX外泌体途径。
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