Penagini R, Spiller R C, Misiewicz J J, Frost P G
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
Gut. 1989 May;30(5):609-17. doi: 10.1136/gut.30.5.609.
The hypothesis that the presence of glycochenodeoxycholic acid (GCDC) in the human Ileal bile acid concentrations showed a 54.0 (9.3)% absorption of glycochenodeoxycholic acid by the been tested in healthy volunteers. Mean transit times, flow rates and intraluminal pressures in a 40 cm jejunal segment proximal (n = 6) and a 40 cm ileal segment distal (n = 6) to a GCDC infusion port were measured. During GCDC infusion (60 mumol/min) jejunal and ileal transit were markedly (p less than 0.05) delayed (31.6 (7.7), mean (SEM) v 14.5 (3.8) min and 37.0 (5.7) v 21.0 (3.5) min, respectively), segment volumes increased (141.1 (30.2) v 59.2 (9.9) ml and 173.2 (26.3) v 83.9 (9.5) ml; p less than 0.05), while flow rates did not change significantly (4.6 (0.6) v 4.5 (0.6) ml/min and 4.8 (0.5) v 4.2 (0.3) ml/min, respectively). Ileal pressures (distal to the GCDC infusion port) decreased (p less than 0.05) promptly (1.0 (0.1) min) after the start of GCDC infusion. Inhibition of jejunal motility was more gradual and reached significance (p less than 0.05) only 30 min after beginning of the infusion. Ileal bile acid concentrations showed a 54.0 (9.3)% absorption of glycochenodeoxycholic acid by the 40 cm ileal segment. These observations suggest the existence of an intestinal control mechanism in healthy man, whereby presence of glycochenodeoxycholic acid in the ileum inhibits motility and delays transit in the jejunum and ileum.
人回肠胆汁酸浓度中甘氨鹅去氧胆酸（GCDC）的存在表明40厘米回肠段对甘氨鹅去氧胆酸的吸收率为54.0（9.3）%。测量了在靠近GCDC输注端口近端的40厘米空肠段（n = 6）和远端的40厘米回肠段（n = 6）的平均转运时间、流速和腔内压力。在GCDC输注期间（60 μmol/分钟），空肠和回肠转运明显延迟（p < 0.05）（分别为31.6（7.7），平均值（标准误）对14.5（3.8）分钟和37.0（5.7）对21.0（3.5）分钟），段体积增加（141.1（30.2）对59.2（9.9）毫升和173.2（26.3）对83.9（9.5）毫升；p < 0.05），而流速没有显著变化（分别为4.6（0.6）对4.5（0.6）毫升/分钟和4.8（0.5）对4.2（0.3）毫升/分钟）。GCDC输注开始后，回肠压力（在GCDC输注端口远端）迅速下降（p < 0.05）（1.0（0.1）分钟）。空肠蠕动的抑制更为缓慢，仅在输注开始后30分钟达到显著水平（p < 0.05）。回肠胆汁酸浓度表明40厘米回肠段对甘氨鹅去氧胆酸的吸收率为54.0（9.3）%。这些观察结果表明健康人体内存在一种肠道控制机制，即回肠中甘氨鹅去氧胆酸的存在会抑制空肠和回肠的蠕动并延迟转运。
