Gao Y S, Yuan Y, Song G, Lin S Q
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong, China.
College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Genet Mol Res. 2016 May 13;15(2):gmr8642. doi: 10.4238/gmr.15028642.
Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) and oleanolic acid (OA) from wild loquat were previously found capable of suppressing the proliferation of A549 cells in vitro. In the current study, nude mice were used to determine the inhibitory effect of UA and OA on tumor formation in vivo. The results demonstrate that UA and OA reduced the proliferation of A549 cells in nude mice, and increased the expression of Bid while decreasing the protein levels of MMP-2, Ki-67, and CD34. In this study, we identified potential antitumor activity in a wild loquat extract containing UA and OA, which demonstrates that traditional Chinese medicine may have a role in treating certain types of cancer.
枇杷[枇杷属（林德利）]是一种传统中药，已被用于抗炎以及治疗慢性支气管炎等其他潜在用途。先前发现从野生枇杷中提取的熊果酸（UA）和齐墩果酸（OA）能够在体外抑制A549细胞的增殖。在本研究中，使用裸鼠来确定UA和OA对体内肿瘤形成的抑制作用。结果表明，UA和OA降低了裸鼠体内A549细胞的增殖，并增加了Bid的表达，同时降低了MMP-2、Ki-67和CD34的蛋白质水平。在本研究中，我们在含有UA和OA的野生枇杷提取物中鉴定出潜在的抗肿瘤活性，这表明传统中药可能在治疗某些类型的癌症中发挥作用。
