Yang S X, Chen F, Zhang J W, Sun Z Q, Chen B P
Department of Nephrology, Huaihe Hospital of Henan University, Kaifeng, Henan, China.
Genet Mol Res. 2016 Jun 10;15(2):gmr7553. doi: 10.4238/gmr.15027553.
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16.0 (SPSS Inc., Chicago, IL, USA). Using conditional logistic regression analysis, the TC and CC genotypes of rs4778889 exhibited a higher risk of RCC, with adjusted ORs (and 95%CIs) of 1.79 (1.23-2.62) and 2.67 (1.29-5.69), respectively. Moreover, under dominant and recessive models, individuals carried the rs4778889 polymorphism was exhibited elevated RCC risk, with adjusted ORs (and 95%CI) of 1.93 (1.35-2.76) and 2.11 (1.05-4.45), respectively. No significant differences were observed in rs11556218 genotype frequencies between the study groups. In conclusion, the results of our study reveal an association between the IL-16 rs4778889 polymorphism and heightened risk of RCC.
白细胞介素-16在影响肿瘤相关炎性细胞因子的分泌中起重要作用。我们旨在评估白细胞介素-16（IL-16）rs4778889 T/C和rs11556218 T/G多态性在肾细胞癌（RCC）发生中的作用。本研究由274例RCC患者和274例对照受试者组成。使用聚合酶链反应结合限制性片段长度多态性分析进行多态性基因分型。所有统计分析均通过SPSS统计软件包16.0版（美国伊利诺伊州芝加哥市SPSS公司）进行。采用条件逻辑回归分析，rs4778889的TC和CC基因型表现出较高的RCC风险，调整后的比值比（及95%可信区间）分别为1.79（1.23 - 2.62）和2.67（1.29 - 5.69）。此外，在显性和隐性模型下，携带rs4778889多态性的个体表现出RCC风险升高，调整后的比值比（及95%可信区间）分别为1.93（1.35 - 2.76）和2.11（1.05 - 4.45）。研究组之间rs11556218基因型频率未观察到显著差异。总之，我们的研究结果揭示了IL-16 rs4778889多态性与RCC风险升高之间的关联。
