Unsworth P F
Department of Microbiology, Tameside General Hospital, Ashton-under-Lyne.
J Clin Pathol. 1989 May;42(5):506-10. doi: 10.1136/jcp.42.5.506.
One hundred and seven (41%) of 262 isolates of Streptococcus milleri, from human sources, produced hyaluronidase. Hyaluronidase production was commoner in beta haemolytic isolates 32 of 39 (82%), many of which were of Lancefield group F. But hyaluronidase was also found in alpha and non-haemolytic isolates, and in groups A, C, G, and non-groupable isolates. There was a strong association between hyaluronidase production and isolation from known internal abscesses (48/58, 83%) compared with isolates from the normal flora of uninfected sites (24/97, 25%). Isolates from 15 patients with endocarditis were uniformly negative, although 13 of 25 (52%) isolates from dental plaque produced the enzyme. Production of hyaluronidase may therefore be an important determinant in the pathogenicity of infection by S milleri and could be helpful in predicting the likelihood of deep purulent lesions in isolates from blood culture.
从人体分离出的262株米勒链球菌中，有107株（41%）产生透明质酸酶。透明质酸酶在β溶血菌株中更为常见，39株中有32株（82%），其中许多属于兰斯菲尔德F组。但在α溶血和非溶血菌株以及A、C、G组和不可分组的菌株中也发现了透明质酸酶。与从未感染部位的正常菌群中分离出的菌株（24/97，25%）相比，产生透明质酸酶与从已知的内部脓肿中分离出的菌株之间存在很强的关联（48/58，83%）。15例心内膜炎患者的分离株均为阴性，尽管从牙菌斑中分离出的25株中有13株（52%）产生该酶。因此，透明质酸酶的产生可能是米勒链球菌感染致病性的一个重要决定因素，并且有助于预测血培养分离株中深部化脓性病变的可能性。
