Ahmed R G
Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Food Chem Toxicol. 2016 Sep;95:168-74. doi: 10.1016/j.fct.2016.06.017. Epub 2016 Jun 17.
Because bisphenol A (BPA) has been detected in animals, the aim of this study was to investigate the possible effects of maternal BPA exposure on the fetal endocrine system (thyroid-adipokine axis). BPA (20 or 40 μg/kg body weight) was orally administered to pregnant rats from gestation day (GD) 1-20. In both treated groups, the dams and their fetuses had lower serum thyroxine (T4) and triiodothyronine (T3) levels, and higher thyrotropin (TSH) level than control dams and fetuses at GD 20. Some histopathological changes in fetal thyroid glands were observed in both maternal BPA groups at embryonic day (ED) 20, including fibroblast proliferation, hyperplasia, luminal obliteration, oedema, and degeneration. These disorders resulted in the suppression of fetal serum growth hormone (GH), insulin growth factor-1 (IGF1) and adiponectin (ADP) levels, and the elevation of fetal serum leptin, insulin and tumor necrosis factor-alpha (TNFα) levels in both treated groups with respect to control. The depraved effects of both treated groups were associated with reduced maternal and fetal body weight compared to the control group. These alterations were dose dependent. Thus, BPA might penetrate the placental barrier and perturb the fetal thyroid adipokine axis to influence fat metabolism and the endocrine system.
由于在动物体内检测到双酚A（BPA），本研究旨在探讨母体暴露于BPA对胎儿内分泌系统（甲状腺-脂肪因子轴）可能产生的影响。从妊娠第1天至第20天，对怀孕大鼠口服给予BPA（20或40μg/kg体重）。在两个处理组中，与妊娠第20天的对照母鼠及其胎儿相比，母鼠及其胎儿的血清甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平较低，促甲状腺激素（TSH）水平较高。在胚胎第20天，两个母体BPA组的胎儿甲状腺均观察到一些组织病理学变化，包括成纤维细胞增殖、增生、管腔闭塞、水肿和变性。相对于对照组，这些紊乱导致两个处理组胎儿血清生长激素（GH）、胰岛素生长因子-1（IGF1）和脂联素（ADP）水平受到抑制，胎儿血清瘦素、胰岛素和肿瘤坏死因子-α（TNFα）水平升高。与对照组相比，两个处理组的不良影响均与母鼠和胎儿体重减轻有关。这些改变具有剂量依赖性。因此，BPA可能穿透胎盘屏障，扰乱胎儿甲状腺脂肪因子轴，从而影响脂肪代谢和内分泌系统。
