Tan Anna C S, Balaratnasingam Chandrakumar, Yannuzzi Lawrence A
Ophthalmic Surg Lasers Imaging Retina. 2016 Jun 1;47(6):528-35. doi: 10.3928/23258160-20160601-04.
To assess the outcomes of patients with macular telangiectasia type 2 (MacTel 2) in response to lutein (L), meso-zeaxanthin (M), and zeaxanthin (Z) supplements (LMZ3).
Thirteen patients diagnosed with MacTel 2 were started on lutein 10 mg, meso-zeaxanthin 10 mg, and zeaxanthin 2 mg and were followed-up for a mean period of 15.7 months ± 4.85 months.
Visual acuity improved in three patients (13%), and there was a reduction in the percentage of patients who had worsening vision (25% to 4%; P < .05). Optical coherence tomography changes showed a reduction in the number of cavitations and the largest diameter of the cavitation after the LMZ3 supplements were started. The largest diameter of photoreceptor disruption showed mild improvement in the first 6 months after LMZ3 supplements were started.
LMZ3 supplements may stabilize vision and improve the cavitations in patients with MacTel 2. Larger randomized, controlled studies are required to verify these pilot results. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:528-535.].
评估2型黄斑毛细血管扩张症（MacTel 2）患者服用叶黄素（L）、中玉米黄质（M）和玉米黄质（Z）补充剂（LMZ3）后的疗效。
13例诊断为MacTel 2的患者开始服用10毫克叶黄素、10毫克中玉米黄质和2毫克玉米黄质，并进行了平均15.7个月±4.85个月的随访。
3例患者（13%）视力提高，视力恶化的患者比例降低（从25%降至4%；P < .05）。光学相干断层扫描结果显示，开始服用LMZ3补充剂后，空洞数量减少，空洞最大直径减小。开始服用LMZ3补充剂后的前6个月，光感受器破坏的最大直径有轻度改善。
LMZ3补充剂可能使MacTel 2患者的视力稳定并改善空洞情况。需要更大规模的随机对照研究来验证这些初步结果。[《眼科手术、激光与视网膜成像》。2016；47：528 - 535。]
