Haake Scott M, Weyandt Jamie D, Rathmell W Kimryn
Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee.
Mol Cancer Res. 2016 Jul;14(7):589-98. doi: 10.1158/1541-7786.MCR-16-0115. Epub 2016 Jun 21.
The renal cell carcinomas (RCC), clear cell, papillary, and chromophobe, have recently undergone an unmatched genomic characterization by The Cancer Genome Atlas. This analysis has revealed new insights into each of these malignancies and underscores the unique biology of clear cell, papillary, and chromophobe RCC. Themes that have emerged include distinct mechanisms of metabolic dysregulation and common mutations in chromatin modifier genes. Importantly, the papillary RCC classification encompasses a heterogeneous group of diseases, each with highly distinct genetic and molecular features. In conclusion, this review summarizes RCCs that represent a diverse set of malignancies, each with novel biologic programs that define new paradigms for cancer biology. Mol Cancer Res; 14(7); 589-98. ©2016 AACR.
肾细胞癌（RCC），包括透明细胞型、乳头状和嫌色细胞型，最近通过癌症基因组图谱进行了无与伦比的基因组特征分析。该分析揭示了对这些恶性肿瘤各自的新见解，并强调了透明细胞型、乳头状和嫌色细胞型肾细胞癌的独特生物学特性。出现的主题包括代谢失调的不同机制和染色质修饰基因的常见突变。重要的是，乳头状肾细胞癌分类涵盖了一组异质性疾病，每种疾病都具有高度独特的遗传和分子特征。总之，本综述总结了代表多种恶性肿瘤的肾细胞癌，每种都有定义癌症生物学新范式的新型生物学程序。《分子癌症研究》；14（7）；589 - 98。©2016美国癌症研究协会。
