Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.
Chem Soc Rev. 2016 Nov 7;45(22):6250-6269. doi: 10.1039/c6cs00458j.
Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-metastasis treatment is thus the key to cure cancer. Recent development in nanomedicine has shown great promise for tackling cancer metastasis. In recent years, nanoparticle-based drug delivery systems have been extensively explored for improving cancer treatment, showing the ability to reduce the risk of tumor metastasis compared with conventional chemotherapy. Photothermal therapy, by employing nano-theranostic agents, has also been found to be able to inhibit lymphatic tumor metastasis. Moreover, the post-immunological effects of certain types of nano-therapies may also be utilized to treat tumor metastasis, presenting an exciting new avenue towards successful cancer treatment. In this review article, we would like to summarize the latest research advances in the development of various emerging nanomedicine approaches for cancer metastasis treatment, and discuss future prospects in this emerging field as well as the clinical translation potential of these techniques.
转移是导致大多数癌症死亡的直接或间接原因。因此，抗转移治疗是治愈癌症的关键。最近纳米医学的发展为治疗癌症转移带来了很大的希望。近年来，基于纳米粒子的药物输送系统被广泛探索用于改善癌症治疗，与传统化疗相比，具有降低肿瘤转移风险的能力。光热疗法通过使用纳米治疗剂，也被发现能够抑制淋巴肿瘤转移。此外，某些类型的纳米疗法的免疫后效应也可用于治疗肿瘤转移，为成功治疗癌症提供了一个令人兴奋的新途径。在这篇综述文章中，我们将总结各种新兴纳米医学方法在癌症转移治疗方面的最新研究进展，并讨论该领域的未来前景以及这些技术的临床转化潜力。
