Department of Bioengineering, University of California, Los Angeles, California, USA.
Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, California, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Sep;12(5):e1632. doi: 10.1002/wnan.1632. Epub 2020 Apr 7.
Cancer immunotherapy aims to leverage the immune system to suppress the growth of tumors and to inhibit metastasis. The recent promising clinical outcomes associated with cancer immunotherapy have prompted research and development efforts towards enhancing the efficacy of immune checkpoint blockade, cancer vaccines, cytokine therapy, and adoptive T cell therapy. Advancements in biomaterials, nanomedicine, and micro-/nano-technology have facilitated the development of enhanced local delivery systems for cancer immunotherapy, which can enhance treatment efficacy while minimizing toxicity. Furthermore, locally administered cancer therapies that combine immunotherapy with chemotherapy, radiotherapy, or phototherapy have the potential to achieve synergistic antitumor effects. Herein, the latest studies on local delivery systems for cancer immunotherapy are surveyed, with an emphasis on the therapeutic benefits associated with the design of biomaterials and nanomedicines. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
癌症免疫疗法旨在利用免疫系统抑制肿瘤生长和抑制转移。最近与癌症免疫疗法相关的有希望的临床结果促使人们进行研究和开发工作，以增强免疫检查点阻断、癌症疫苗、细胞因子疗法和过继性 T 细胞疗法的疗效。生物材料、纳米医学和微/纳米技术的进步促进了癌症免疫疗法增强型局部递药系统的发展，这可以提高治疗效果，同时最大限度地降低毒性。此外，将免疫疗法与化疗、放疗或光疗相结合的局部癌症疗法有可能实现协同抗肿瘤作用。本文综述了癌症免疫疗法的局部递药系统的最新研究进展，重点介绍了生物材料和纳米医学设计相关的治疗益处。本文属于以下分类： 生物技术 > 纳米系统在生物学中的应用 治疗方法和药物发现 > 用于肿瘤疾病的纳米医学。
