风险预测、筛查和诊断测试中的谱效应。
The spectrum effect in tests for risk prediction, screening, and diagnosis.
作者信息
Usher-Smith Juliet A, Sharp Stephen J, Griffin Simon J
机构信息
The Primary Care Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Cambridge, UK.
出版信息
BMJ. 2016 Jun 22;353:i3139. doi: 10.1136/bmj.i3139.
The spectrum effect describes the variation between settings in performance of tests used to predict, screen for, and diagnose disease. In particular, the predictive use of a test may be different when it is applied in a general population rather than in the study sample in which it was first developed. This article discusses the impact of the spectrum effect on measures of test performance, and its implications for the development, evaluation, application, and implementation of such tests.
谱效应描述了用于预测、筛查和诊断疾病的测试在不同环境下性能的差异。特别是，当一项测试应用于普通人群而非其最初开发时所使用的研究样本时，其预测用途可能会有所不同。本文讨论了谱效应对测试性能指标的影响，以及它对这类测试的开发、评估、应用和实施的启示。
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