骨髓细胞的表观遗传调控
Epigenetic Regulation of Myeloid Cells.
机构信息
Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021.
Department of Medicine and Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY 10021.
出版信息
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0010-2015.
Abstract
Epigenetic regulation in myeloid cells is crucial for cell differentiation and activation in response to developmental and environmental cues. Epigenetic control involves posttranslational modification of DNA or chromatin, and is also coupled to upstream signaling pathways and transcription factors. In this review, we summarize key epigenetic events and how dynamics in the epigenetic landscape of myeloid cells shape the development, immune activation, and innate immune memory.
摘要
在骨髓细胞中，表观遗传调控对于细胞分化和对发育及环境信号的响应激活至关重要。表观遗传调控涉及 DNA 或染色质的翻译后修饰，也与上游信号通路和转录因子相关联。在这篇综述中，我们总结了关键的表观遗传事件，以及骨髓细胞表观遗传景观的动态变化如何塑造其发育、免疫激活和固有免疫记忆。
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