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阿片类物质使用障碍

Opioid Use Disorders.

作者信息

Sharma Bikash, Bruner Ann, Barnett Gabrielle, Fishman Marc

机构信息

Mountain Manor Treatment Center, Baltimore, MD, USA.

Mountain Manor Treatment Center, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Child Adolesc Psychiatr Clin N Am. 2016 Jul;25(3):473-87. doi: 10.1016/j.chc.2016.03.002. Epub 2016 Apr 9.

DOI:10.1016/j.chc.2016.03.002
PMID:27338968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4920977/
Abstract

Opioid use and addiction in adolescents and young adults is a health problem of epidemic proportions, with devastating consequences for youth and their families. Opioid overdose is a life-threatening emergency that should be treated with naloxone, and respiratory support if necessary. Overdose should always be an opportunity to initiate addiction treatment. Detoxification is often a necessary, but never sufficient, component of treatment for OUDs. Treatment for OUDs is effective but treatment capacity is alarmingly limited and under-developed. Emerging consensus supports the incorporation of relapse prevention medications such as buprenorphine and extended release naltrexone into comprehensive psychosocial treatment including counseling and family involvement.

摘要

青少年和青年中的阿片类药物使用及成瘾是一个具有流行程度的健康问题,给青少年及其家庭带来了毁灭性后果。阿片类药物过量是一种危及生命的紧急情况,应使用纳洛酮进行治疗,必要时给予呼吸支持。过量用药始终应成为启动成瘾治疗的契机。脱毒往往是阿片类药物使用障碍治疗的一个必要但绝不充分的组成部分。阿片类药物使用障碍的治疗是有效的,但治疗能力却极其有限且发展不足。新出现的共识支持将丁丙诺啡和长效纳曲酮等预防复发药物纳入包括咨询和家庭参与在内的综合心理社会治疗中。

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本文引用的文献

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Evidence of CNIH3 involvement in opioid dependence.CNIH3参与阿片类药物依赖的证据。
Mol Psychiatry. 2016 May;21(5):608-14. doi: 10.1038/mp.2015.102. Epub 2015 Aug 4.
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Progression to regular heroin use: examination of patterns, predictors, and consequences.向常规海洛因使用的进展:模式、预测因素及后果的研究
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Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.1999 - 2011年美国涉及阿片类镇痛药的药物中毒死亡情况
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Medication-assisted therapies--tackling the opioid-overdose epidemic.药物辅助治疗——应对阿片类药物过量流行问题
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Motives for medical misuse of prescription opioids among adolescents.青少年处方阿片类药物滥用的动机。
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Patient characteristics associated with buprenorphine/naloxone treatment outcome for prescription opioid dependence: Results from a multisite study.与丁丙诺啡/纳洛酮治疗处方类阿片依赖治疗结局相关的患者特征:一项多中心研究的结果。
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