Dávila-Céspedes Antonio, Hufendiek Peter, Crüsemann Max, Schäberle Till F, König Gabriele M
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
Beilstein J Org Chem. 2016 May 13;12:969-984. doi: 10.3762/bjoc.12.96. eCollection 2016.
Myxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent discovery and due to the fact that their very existence was called into question. The to-date-explored members of these halophilic or halotolerant myxobacteria are all grouped into the suborder Nannocystineae. Few of them were chemically investigated revealing around 11 structural types belonging to the polyketide, non-ribosomal peptide, hybrids thereof or terpenoid class of secondary metabolites. A most unusual structural type is represented by salimabromide from Enhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria.
粘细菌以其产生极其有趣的次生代谢产物的能力而闻名。直到最近，只有陆生粘细菌是研究的焦点。然而，在本综述中，我们讨论了源自海洋的粘细菌，由于它们相对较新的发现以及它们的存在曾受到质疑这一事实，它们特别有趣。这些嗜盐或耐盐粘细菌迄今为止所探索的成员都被归入囊球菌亚目。其中很少有进行过化学研究，揭示出约11种结构类型，属于聚酮化合物、非核糖体肽、它们的杂合体或次生代谢产物的萜类。一种最不寻常的结构类型由来自盐沼粘球菌的盐沼溴菌素代表。对囊球菌亚目的四个细菌成员的可用基因组序列进行了计算机分析，揭示了这些细菌的生物合成潜力。
