量化人类免疫缺陷病毒的传染性。
Quantifying the infectivity of human immunodeficiency virus.
作者信息
Layne S P, Spouge J L, Dembo M
机构信息
Theoretical Division, Los Alamos National Laboratory, NM 87545.
出版信息
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4644-8. doi: 10.1073/pnas.86.12.4644.
Abstract
We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these parameters from well-mixed infectivity assays. We discuss the implications of the model for our understanding of the infectious process and virulence of HIV in vivo.
摘要
我们已经开发出一种数学模型，该模型可量化人类免疫缺陷病毒（HIV）对淋巴细胞的感染以及诸如可溶性CD4等阻断剂对淋巴细胞的保护作用。我们使用此模型来建议用于量化病毒感染性的标准化参数，并建议从充分混合的感染性试验中计算这些参数的技术。我们讨论了该模型对于我们理解HIV在体内的感染过程和毒力的意义。
相似文献
1
Quantifying the infectivity of human immunodeficiency virus.量化人类免疫缺陷病毒的传染性。
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4644-8. doi: 10.1073/pnas.86.12.4644.
2
Analytic results for quantifying HIV infectivity.用于量化HIV传染性的分析结果。
Bull Math Biol. 1989;51(6):715-30. doi: 10.1007/BF02459657.
3
Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression.一种对CD4表达有异常影响的非细胞病变性HIV-2毒株的特征分析。
Science. 1988 Jun 10;240(4858):1522-5. doi: 10.1126/science.2836951.
4
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.人类免疫缺陷病毒：传染性与发病机制
Science. 1988 Feb 5;239(4840):617-22. doi: 10.1126/science.3277274.
5
Pathogenesis of human immunodeficiency virus infection.人类免疫缺陷病毒感染的发病机制
Ann N Y Acad Sci. 1989;567:58-68. doi: 10.1111/j.1749-6632.1989.tb16459.x.
6
Diversity and virulence thresholds in AIDS.艾滋病中的多样性和毒力阈值
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):544-8. doi: 10.1073/pnas.91.2.544.
7
The AIDS virus.艾滋病病毒。
Sci Am. 1987 Jan;256(1):46-56.
8
Questions about HIV causing AIDS? Viral load and T-cell (CD4) counts: why they really matter.关于艾滋病毒导致艾滋病的疑问？病毒载量和T细胞（CD4）计数：它们为何至关重要。
AIDS Treat News. 2001 May 11(364):7-8.
9
[Isolation of human immunodeficiency virus from Hungarian AIDS and ARC patients].[从匈牙利艾滋病和艾滋病相关综合征患者中分离出人类免疫缺陷病毒]
Orv Hetil. 1990 Apr 29;131(17):895-8.
10
[Different sensitivity to acid reaction of the AIDS virus and virus-producing cells: clinical conclusions].[艾滋病病毒与病毒产生细胞对酸反应的不同敏感性：临床结论]
Orv Hetil. 1990 Sep 9;131(36):1959-64.
引用本文的文献
1
Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.自体干细胞移植在猿猴/人类免疫缺陷病毒血症反弹期间破坏适应性免疫反应。
J Virol. 2017 Jun 9;91(13). doi: 10.1128/JVI.00095-17. Print 2017 Jul 1.
2
A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection.人类免疫缺陷病毒感染中病毒水平与特定免疫反应机制的弹性比较。
BMC Res Notes. 2014 Oct 20;7:737. doi: 10.1186/1756-0500-7-737.
3
A hunter virus that targets both infected cells and HIV free virions: implications for therapy.一种靶向受感染细胞和游离HIV病毒体的猎手病毒：对治疗的启示。
Theor Biol Med Model. 2012 Dec 6;9:52. doi: 10.1186/1742-4682-9-52.
4
Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1.用于优化药物递送以影响HIV-1治疗中选择压力的进化博弈论策略。
J Math Biol. 2012 Feb;64(3):495-512. doi: 10.1007/s00285-011-0422-8. Epub 2011 Apr 19.
5
Effectiveness of a 'hunter' virus in controlling human immunodeficiency virus type 1 infection.“猎人”病毒控制人类免疫缺陷病毒 1 型感染的有效性。
J Gen Virol. 2010 Oct;91(Pt 10):2513-23. doi: 10.1099/vir.0.023028-0. Epub 2010 Jun 23.
6
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.实时成像揭示了伯氏疏螺旋体在蜱体内的两相传播模式。
J Clin Invest. 2009 Dec;119(12):3652-65. doi: 10.1172/JCI39401. Epub 2009 Nov 16.
7
A practical method for simultaneously determining the effective burst sizes and cycle times of viruses.一种同时测定病毒有效爆发大小和循环时间的实用方法。
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7017-22. doi: 10.1073/pnas.96.12.7017.
8
Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.抗体和可溶性CD4介导的对人免疫缺陷病毒1型原代分离株和T细胞系适应株中和作用的定量模型
J Virol. 1996 Jun;70(6):3668-77. doi: 10.1128/JVI.70.6.3668-3677.1996.
9
Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity.猿猴免疫缺陷病毒包膜糖蛋白胞质结构域的截短增加了env蛋白掺入病毒颗粒的量以及融合性和感染性。
J Virol. 1993 May;67(5):2824-31. doi: 10.1128/JVI.67.5.2824-2831.1993.
10
Viral multiplicity of attachment and its implications for human immunodeficiency virus therapies.病毒附着的多重性及其对人类免疫缺陷病毒治疗的影响。
J Virol. 1994 Mar;68(3):1782-9. doi: 10.1128/JVI.68.3.1782-1789.1994.
本文引用的文献
1
Fusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extent.低pH条件下流感病毒与心磷脂脂质体的融合：动力学和融合程度的质量作用分析
Biochemistry. 1986 Jan 14;25(1):257-66. doi: 10.1021/bi00349a036.
2
Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins.人类免疫缺陷病毒（HIV）的精细结构及结构蛋白的免疫定位
Virology. 1987 Jan;156(1):171-6. doi: 10.1016/0042-6822(87)90449-1.
3
Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1.1型人类免疫缺陷病毒包膜糖蛋白的功能区
Science. 1987 Sep 11;237(4820):1351-5. doi: 10.1126/science.3629244.
4
Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen.可溶性分泌形式的CD4抗原对HIV-1感染性的阻断作用。
Science. 1987 Dec 18;238(4834):1704-7. doi: 10.1126/science.3500514.
5
Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody.用于检测人类免疫缺陷病毒中和抗体的简单、快速、定量、形成合胞体的微量测定法。
AIDS Res Hum Retroviruses. 1987 Fall;3(3):283-302. doi: 10.1089/aid.1987.3.283.
6
The organization of the envelope projections on the surface of HIV.HIV表面包膜突起的结构
Arch Virol. 1988;100(3-4):255-66. doi: 10.1007/BF01487688.
7
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.人类免疫缺陷病毒：传染性与发病机制
Science. 1988 Feb 5;239(4840):617-22. doi: 10.1126/science.3277274.
8
Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4.人类免疫缺陷病毒的内化不需要CD4的胞质结构域。
Nature. 1988 Jul 14;334(6178):162-5. doi: 10.1038/334162a0.
9
A soluble form of CD4 (T4) protein inhibits AIDS virus infection.可溶性形式的CD4（T4）蛋白可抑制艾滋病病毒感染。
Nature. 1988 Jan 7;331(6151):82-4. doi: 10.1038/331082a0.
10
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.pH 非依赖性的 HIV 通过病毒包膜与质膜融合进入 CD4 阳性 T 细胞。
Cell. 1987 Jun 5;49(5):659-68. doi: 10.1016/0092-8674(87)90542-3.
Zotero 插件