ZIEL Institute for Food and Health, Clinical Nutritional Medicine, Technical University of Munich, Munich, Germany;
Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Food Nutr Res. 2016 Jun 23;60:30298. doi: 10.3402/fnr.v60.30298. eCollection 2016.
For the increasing development of type 2 diabetes dietary habits play an important role. In this regard, dietary supplements are of growing interest to influence the progression of this disease.
The aim of this study was to investigate the effect of a cascade-fermented dietary supplement based on fruits, nuts, and vegetables fortified with chromium and zinc on metabolic control in patients with type 2 diabetes mellitus.
This was a randomized, placebo-controlled, double-blind, intervention study under free-living conditions using a cross-over design. Thirty-six patients with type 2 diabetes mellitus were enrolled and randomized either to receive a cascade-fermented dietary supplement enriched with chromium (100 µg/d) and zinc (15 mg/d) or a placebo similar in taste but without supplements, over a period of 12 weeks. After a wash-out period of 12 weeks, the patients received the other test product. The main outcome variable was the levels of glycated hemoglobin (HbA1c). Other outcome variables were fasting blood glucose, fructosamine, and lipid parameters.
Thirty-one patients completed the study. HbA1c showed no relevant changes during both treatment periods, nor was there a relevant difference between the two treatments (HbA1c: p=0.48). The same results were found for fructosamine and fasting glucose (fructosamine: p=0.9; fasting glucose: p=0.31). In addition, there was no effect on lipid metabolism.
This intervention study does not provide evidence that a cascade-fermented plant-based dietary supplement enriched with a combination of chromium and zinc improves glucose metabolism in patients with type 2 diabetes mellitus under free-living conditions.
对于 2 型糖尿病的日益发展，饮食习惯起着重要作用。在这方面，膳食补充剂对于影响疾病进展的兴趣日益增加。
本研究旨在探讨基于水果、坚果和蔬菜的级联发酵膳食补充剂，强化铬和锌对 2 型糖尿病患者代谢控制的影响。
这是一项在自由生活条件下使用交叉设计的随机、安慰剂对照、双盲、干预研究。纳入了 36 名 2 型糖尿病患者，并随机分为接受富含铬（100μg/d）和锌（15mg/d）的级联发酵膳食补充剂或口感相似但不含补充剂的安慰剂组，为期 12 周。经过 12 周的洗脱期后，患者接受另一种测试产品。主要观察变量为糖化血红蛋白（HbA1c）水平。其他观察变量包括空腹血糖、果糖胺和血脂参数。
31 名患者完成了研究。在两个治疗期间，HbA1c 均无明显变化，两种治疗之间也无明显差异（HbA1c：p=0.48）。果糖胺和空腹血糖也有同样的结果（果糖胺：p=0.9；空腹血糖：p=0.31）。此外，对脂质代谢没有影响。
本干预研究并未提供证据表明，富含铬和锌的级联发酵植物性膳食补充剂可改善 2 型糖尿病患者在自由生活条件下的葡萄糖代谢。
