Umemura Atsushi, Oyama Genko, Shimo Yasushi, Nakajima Madoka, Nakajima Asuka, Jo Takayuki, Sekimoto Satoko, Ito Masanobu, Mitsuhashi Takumi, Hattori Nobutaka, Arai Hajime
Department of Research and Therapeutics for Movement Disorders, Juntendo University Graduate School of Medicine.
Neurol Med Chir (Tokyo). 2016 Oct 15;56(10):613-625. doi: 10.2176/nmc.ra.2016-0021. Epub 2016 Jun 24.
There is a long history of surgical treatment for Parkinson disease (PD). After pioneering trials and errors, the current primary surgical treatment for PD is deep brain stimulation (DBS). DBS is a promising treatment option for patients with medically refractory PD. However, there are still many problems and controversies associated with DBS. In this review, we discuss current issues in DBS for PD, including patient selection, clinical outcomes, complications, target selection, long-term outcomes, management of axial symptoms, timing of surgery, surgical procedures, cost-effectiveness, and new technology.
帕金森病（PD）的外科治疗有着悠久的历史。在经历了开创性的试验和错误之后，目前PD的主要外科治疗方法是脑深部电刺激（DBS）。DBS对于药物难治性PD患者是一种有前景的治疗选择。然而，DBS仍存在许多问题和争议。在本综述中，我们讨论了PD的DBS当前存在的问题，包括患者选择、临床疗效、并发症、靶点选择、长期疗效、轴性症状的管理、手术时机、手术操作、成本效益以及新技术。
