Norris A A, Jackson D M
Department of Pharmacology, Research Laboratory, Fisons plc, Loughborough, Leicestershire, UK.
Agents Actions. 1989 Mar;26(3-4):360-6. doi: 10.1007/BF01967302.
Anaesthetised Beagle dogs were exposed to sulphur-dioxide (SO2) for 2 h and the pulmonary effects studied up to 24 h using bronchoalveolar lavage (BAL) and lung mechanics measurements. SO2-induced hyperreactivity to histamine was associated with epithelial cell shedding, an increase in airway permeability to plasma proteins and an increase in BAL PGE2 content. Leukotrienes were not recovered in BAL. Ibuprofen reduced hyperreactivity at 24 h post SO2 but not immediately after SO2 and had no effect on BAL cells at anytime. These results suggest that 2 phases of hyperreactivity exist--an immediate effect which may involve epithelial cell loss and a later phase which may be inflammatory.
将麻醉后的比格犬暴露于二氧化硫（SO2）中2小时，并使用支气管肺泡灌洗（BAL）和肺力学测量方法，对长达24小时的肺部效应进行研究。SO2诱导的对组胺的高反应性与上皮细胞脱落、气道对血浆蛋白通透性增加以及BAL中PGE2含量增加有关。在BAL中未检测到白三烯。布洛芬在SO2暴露后24小时降低了高反应性，但在SO2暴露后立即没有效果，并且在任何时候对BAL细胞都没有影响。这些结果表明存在两个高反应性阶段——一个可能涉及上皮细胞丢失的即时效应和一个可能是炎症性的后期阶段。
