N-杂环分子封端的金纳米粒子作为有效抗生素对抗多重耐药菌。
N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria.
机构信息
College of Resources and Environmental Sciences, China Agricultural University, 2 YuanMingYuan West Road, HaiDian District, Beijing 100193, China.
出版信息
Nanoscale. 2016 Jul 21;8(27):13223-7. doi: 10.1039/c6nr03317b. Epub 2016 Jun 29.
PMID:27355451
Abstract
We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs.
摘要
我们证明了含氮杂环分子包覆的金纳米粒子（Au NPs）具有广谱抗菌活性。通过使用不同的初始摩尔比（1：1 和 10：1）的含氮杂环前药和 Au NPs 的前体（HAuCl4），可以实现优化的抗菌活性。这项工作为基于 Au NPs 的抗生素开辟了新途径。
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