He Liuqin, Zhou Xihong, Huang Niu, Li Huan, Tian Junquan, Li Tiejun, Yao Kang, Nyachoti Clares M, Kim Sung Woo, Yin Yulong
Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South- Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125. China.
College Of Animal Science And Technology, Hunan Agricultural University, Hunan. China.
Curr Protein Pept Sci. 2017;18(6):562-570. doi: 10.2174/1389203717666160627071125.
AMP-activated protein kianse (AMPK) is a master sensor of cellular energy levels and a crucial regulator of nutrient metabolism such as the synthesis of fatty acids, glucose and protein as well as their oxidation to CO2 and water . Thus, AMPK signaling has important implications for fat deposition and glucose homeostasis in animals and humans. Much experimental and clinical evidence show that AMPK is a key therapeutic target for the prevention of diseases such as obesity, diabetes, cancer, inflammation and cardiac dysfunction. In this review we highlight recent advances on the upstream and downstream targets of AMPK, as well as the specific mechanisms whereby AMPK regulates digestive functions and chronic energy balance in animals and humans.
AMP激活的蛋白激酶（AMPK）是细胞能量水平的主要传感器，也是营养物质代谢的关键调节因子，如脂肪酸、葡萄糖和蛋白质的合成以及它们氧化为二氧化碳和水的过程。因此，AMPK信号传导对动物和人类的脂肪沉积和葡萄糖稳态具有重要意义。大量实验和临床证据表明，AMPK是预防肥胖、糖尿病、癌症、炎症和心脏功能障碍等疾病的关键治疗靶点。在这篇综述中，我们重点介绍了AMPK上游和下游靶点的最新进展，以及AMPK调节动物和人类消化功能和慢性能量平衡的具体机制。
